Biomimetic coatings vs. collagen sponges as a carrier for BMP-2: A comparison of the osteogenic responses triggered in vivo using an ectopic rat model

Y. Liu, E.B. Hunziker, C. Van de Vaal, K. de Groot

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    6 Citations (Scopus)


    We have developed a new carrier system for bone morphogenetic protein 2 (BMP-2). This agent has been successfully incorporated into biomimetic calcium phosphate implant coatings without losing its osteoinductive potency. Numerous materials have been tested for their efficiency in carrying BMP-2 and in promoting its osteoinductive effects at both ectopic and orthotopic sites. In the present study, we compare the osteoinductive effects of BMP-2 delivered by biomimetic coatings and by classical collagen sponges in vivo using an ectopic rat model. Titanium-alloy discs, either bearing a co-precipitated layer of calcium phosphate and BMP-2 (1.7 μg/disc) or inserted into collagen sponges impregnated with the same drug (10 μg/sponge), were implanted subcutaneously in the dorsal region of rats and the bone-formation process monitored after 2 and 5 weeks. After 2 weeks, the net volume of bone formed in the biomimetic coating group (5.8 mm3/disc) was greater (p < 0.01) than in the collagen sponge one (2.3 mm3/sponge). By the end of the fifth week, the net volume of bone deposited had increased significantly (p < 0.001) in the biomimetic coating group (11.6 mm3/disc), whereas in the collagen sponge one it remained unchanged. (3.0 mm3/sponge; p = 0.82). As a carrier for BMP-2 and in facilitating its osteogenic effects, biomimetic calcium phosphate coatings offer a distinct advantage over the classical collagen sponge.
    Original languageEnglish
    Title of host publicationBioceramics 16
    EditorsMário A. Barbosa, Fernando J. Monteiro, Rui Correia, Betty Leon
    PublisherTrans Tech Publications Ltd
    Publication statusPublished - 6 Nov 2004
    Event16th International Symposium on Ceramics in Medicine, Bioceramics 16: Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
    Duration: 6 Nov 20039 Nov 2003
    Conference number: 16

    Publication series

    NameKey Engineering Materials
    PublisherTrans Tech Publications
    ISSN (Print)1662-9795
    ISSN (Electronic)1013-9826


    Conference16th International Symposium on Ceramics in Medicine, Bioceramics 16
    Abbreviated titleBioceramics


    • METIS-237066

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