Biomineralization in vivo by substained release of inorganic phosphate ions

Pamela Habibovic; David C. Bassett; Charles J. Doillon; Catherine Gerard; Marc D. McKee; Jake E. Barralet

doi:10.1002/adma.200902778

Biomineralization in vivo by substained release of inorganic phosphate ions

Pamela Habibovic, David C. Bassett, Charles J. Doillon, Catherine Gerard, Marc D. McKee, Jake E. Barralet

Faculty of Science and Technology

Research output: Contribution to journal › Article › Academic › peer-review

69 Citations (Scopus)

6 Downloads (Pure)

Abstract

A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

Original language	Undefined
Pages (from-to)	1858-1862
Journal	Advanced materials
Volume	22
Issue number	16
DOIs	https://doi.org/10.1002/adma.200902778
Publication status	Published - 2010

Keywords

IR-80798
Calcium phosphate
Bone
METIS-267670
Collagen
Graft
Regeneration
Biomineralization

Access to Document

10.1002/adma.200902778

Cite this

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title = "Biomineralization in vivo by substained release of inorganic phosphate ions",

abstract = "A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.",

keywords = "IR-80798, Calcium phosphate, Bone, METIS-267670, Collagen, Graft, Regeneration, Biomineralization",

author = "Pamela Habibovic and Bassett, {David C.} and Doillon, {Charles J.} and Catherine Gerard and McKee, {Marc D.} and Barralet, {Jake E.}",

year = "2010",

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language = "Undefined",

volume = "22",

pages = "1858--1862",

journal = "Advanced materials",

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T1 - Biomineralization in vivo by substained release of inorganic phosphate ions

AU - Habibovic, Pamela

AU - Bassett, David C.

AU - Doillon, Charles J.

AU - Gerard, Catherine

AU - McKee, Marc D.

AU - Barralet, Jake E.

PY - 2010

Y1 - 2010

N2 - A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

AB - A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

KW - IR-80798

KW - Calcium phosphate

KW - Bone

KW - METIS-267670

KW - Collagen

KW - Graft

KW - Regeneration

KW - Biomineralization

U2 - 10.1002/adma.200902778

DO - 10.1002/adma.200902778

M3 - Article

SN - 0935-9648

VL - 22

SP - 1858

EP - 1862

JO - Advanced materials

JF - Advanced materials

IS - 16

ER -