Biomineralization in vivo by substained release of inorganic phosphate ions

Pamela Habibovic, David C. Bassett, Charles J. Doillon, Catherine Gerard, Marc D. McKee, Jake E. Barralet

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65 Citations (Scopus)


A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.
Original languageUndefined
Pages (from-to)1858-1862
JournalAdvanced materials
Issue number16
Publication statusPublished - 2010


  • IR-80798
  • Calcium phosphate
  • Bone
  • METIS-267670
  • Collagen
  • Graft
  • Regeneration
  • Biomineralization

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