Biophotonic sensors on a microchip for trace-gas detection, DNA and enzyme analysis, Raman spectroscopy, and optical coherence tomography

Markus Pollnau, B.I. Akça, N. Ismail, C. Dongre, P.V.S. Pham Van So, Kerstin Worhoff, R.M. de Ridder, Hugo Hoekstra

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    Use of optical principles for the detection and analysis of biomolecules and biotissue has a long-standing tradition, and highly sensitive optical methods have been developed. Integration on a microchip offers cost reduction and instrument miniaturization, thus enabling novel applications, but also allows reduced biosample volumes, higher sensitivity, and faster acquisition times. We demonstrate optical sensing with Bragg-grating cavities inscribed into optical waveguides for label-free sensing of antibody-antigen protein reactions and H2 gas sensing by stress-induced Pd-receptor microcantilever deflections. Furthermore, we introduce the method of modulation-frequency-encoded multi-wavelength fluorescent DNA analysis in an optofluidic chip during capillary electrophoresis separation, enabling detection down to the single-molecule level and allowing simultaneous analysis of DNA fragments from independent human genomic segments, associated with genetic predispositions to breast cancer and anemia, in a single experiment. Finally, by integrating wavelength-selective arrayed-waveguide gratings on a microchip, we demonstrate on-chip Raman spectroscopy and spectral-domain optical coherence tomography of biotissue.
    Original languageUndefined
    Title of host publicationJoint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society
    Place of PublicationBasel
    PublisherSwiss Physical Society
    PagesPaper 213
    Number of pages1
    ISBN (Print)not assigned
    Publication statusPublished - Jun 2011
    EventJoint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society 2011: Joint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society - EPF, Lausanne, Switzerland
    Duration: 15 Jun 201117 Jun 2011
    https://www.sps.ch/en/events/joint-annual-meeting-2011/

    Publication series

    NameBulletin SPG / SSP
    PublisherSwiss Physical Society
    Volume28

    Conference

    ConferenceJoint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society 2011
    CountrySwitzerland
    CityLausanne
    Period15/06/1117/06/11
    Internet address

    Keywords

    • METIS-277671
    • IR-77565
    • EWI-20247
    • IOMS-PCS: PHOTONIC CRYSTAL STRUCTURES
    • IOMS-PIT: PHOTONICS INTEGRATION TECHNOLOGY
    • IOMS-SNS: SENSORS

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