Abstract
Use of optical principles for the detection and analysis of biomolecules and biotissue has a long-standing tradition, and highly sensitive optical methods have been developed. Integration on a microchip offers cost reduction and instrument miniaturization, thus enabling novel applications, but also allows reduced biosample volumes, higher sensitivity, and faster acquisition times. We demonstrate optical sensing with Bragg-grating cavities inscribed into optical waveguides for label-free sensing of antibody-antigen protein reactions and H2 gas sensing by stress-induced Pd-receptor microcantilever deflections. Furthermore, we introduce the method of modulation-frequency-encoded multi-wavelength fluorescent DNA analysis in an optofluidic chip during capillary electrophoresis separation, enabling detection down to the single-molecule level and allowing simultaneous analysis of DNA fragments from independent human genomic segments, associated with genetic predispositions to breast cancer and anemia, in a single experiment. Finally, by integrating wavelength-selective arrayed-waveguide gratings on a microchip, we demonstrate on-chip Raman spectroscopy and spectral-domain optical coherence tomography of biotissue.
Original language | Undefined |
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Title of host publication | Joint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society |
Place of Publication | Basel |
Publisher | Swiss Physical Society |
Pages | Paper 213 |
Number of pages | 1 |
ISBN (Print) | not assigned |
Publication status | Published - Jun 2011 |
Event | Joint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society 2011: Joint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society - EPF, Lausanne, Switzerland Duration: 15 Jun 2011 → 17 Jun 2011 https://www.sps.ch/en/events/joint-annual-meeting-2011/ |
Publication series
Name | Bulletin SPG / SSP |
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Publisher | Swiss Physical Society |
Volume | 28 |
Conference
Conference | Joint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society 2011 |
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Country/Territory | Switzerland |
City | Lausanne |
Period | 15/06/11 → 17/06/11 |
Internet address |
Keywords
- METIS-277671
- IR-77565
- EWI-20247
- IOMS-PCS: PHOTONIC CRYSTAL STRUCTURES
- IOMS-PIT: PHOTONICS INTEGRATION TECHNOLOGY
- IOMS-SNS: SENSORS