Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells

C. Lin, W.E. Hennink (Editor), Zhiyuan Zhong, J. Feijen (Editor), A.P. Sam (Editor), Martin C. Lok, Holger K. de Wolf, Jan Feijen, Johannes F.J. Engbersen

Research output: Contribution to conferencePaper

Abstract

Bioreducible poly(amido amine)s (SS-PAAs) with different groups in the side chain were evaluated for gene delivery to ovarian cancer cells, both in vitro and in vivo after intraperitoneal administration in mice bearing an ovarian cancer xenograft. Polyplexes of SS-PAAs with e.g. hydroxybutyl or hydroxypentyl side groups induce much higher transfection in vitro than polyplexes of branched pEI (25 kDa) as a positive control. The in vivo transfection efficiency of polyplexes of SS-PAA with hydroxybutyl side groups is similar to that of linear pEI (22 kDa).
Original languageUndefined
Pagese9-e10
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Keywords

  • IR-69287
  • METIS-254623

Cite this