Bioreducible poly(amido amine)s (SS-PAAs) with different groups in the side chain were evaluated for gene delivery to ovarian cancer cells, both in vitro and in vivo after intraperitoneal administration in mice bearing an ovarian cancer xenograft. Polyplexes of SS-PAAs with e.g. hydroxybutyl or hydroxypentyl side groups induce much higher transfection in vitro than polyplexes of branched pEI (25 kDa) as a positive control. The in vivo transfection efficiency of polyplexes of SS-PAA with hydroxybutyl side groups is similar to that of linear pEI (22 kDa).
|Publication status||Published - 2 Apr 2008|
|Event||10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands|
Duration: 2 Apr 2008 → 4 Apr 2008
Conference number: 10
|Conference||10th European Symposium on Controlled Drug Delivery, ESCDD 2008|
|City||Noordwijk aan Zee|
|Period||2/04/08 → 4/04/08|