Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells

C. Lin; Z.Y. Zhong; M.C. Lok; H.K. de Wolf; W.E. Hennink; J. Feijen; J.F.J. Engbersen

doi:10.1016/j.jconrel.2008.09.045

Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells

C. Lin
, Z.Y. Zhong
, M.C. Lok
, H.K. de Wolf
, W.E. Hennink
, J. Feijen
, J.F.J. Engbersen

Research output: Contribution to journal › Meeting Abstract › Academic

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Abstract

Bioreducible poly(amido amine)s (SS-PAAs) with different groups in the side chain were evaluated for gene delivery to ovarian cancer cells, both in vitro and in vivo after intraperitoneal administration in mice bearing an ovarian cancer xenograft. Polyplexes of SS-PAAs with e.g. hydroxybutyl or hydroxypentyl side groups induce much higher transfection in vitro than polyplexes of branched pEI (25 kDa) as a positive control. The in vivo transfection efficiency of polyplexes of SS-PAA with hydroxybutyl side groups is similar to that of linear pEI (22 kDa).

Original language	English
Pages (from-to)	e9-e10
Journal	Journal of controlled release
Volume	132
Issue number	3
DOIs	https://doi.org/10.1016/j.jconrel.2008.09.045
Publication status	Published - 2008
Event	10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands Duration: 2 Apr 2008 → 4 Apr 2008 Conference number: 10

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.jconrel.2008.09.045

1 Paper

Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells
Lin, C., Zhong, Z. Y., Lok, M. C., de Wolf, H. K., Hennink, W. E., Feijen, J. & Engbersen, J. J., 2 Apr 2008, p. 94-97.
Research output: Contribution to conference › Paper

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@article{b190f1bd2a5c4c3b934dccdd6b5e3fbe,

title = "Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells",

abstract = "Bioreducible poly(amido amine)s (SS-PAAs) with different groups in the side chain were evaluated for gene delivery to ovarian cancer cells, both in vitro and in vivo after intraperitoneal administration in mice bearing an ovarian cancer xenograft. Polyplexes of SS-PAAs with e.g. hydroxybutyl or hydroxypentyl side groups induce much higher transfection in vitro than polyplexes of branched pEI (25 kDa) as a positive control. The in vivo transfection efficiency of polyplexes of SS-PAA with hydroxybutyl side groups is similar to that of linear pEI (22 kDa).",

author = "C. Lin and Z.Y. Zhong and M.C. Lok and \{de Wolf\}, H.K. and W.E. Hennink and J. Feijen and J.F.J. Engbersen",

year = "2008",

doi = "10.1016/j.jconrel.2008.09.045",

language = "English",

volume = "132",

pages = "e9--e10",

journal = "Journal of controlled release",

issn = "0168-3659",

publisher = "Elsevier",

number = "3",

note = "10th European Symposium on Controlled Drug Delivery, ESCDD 2008, ESCDD ; Conference date: 02-04-2008 Through 04-04-2008",

}

TY - JOUR

T1 - Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells

AU - Lin, C.

AU - Zhong, Z.Y.

AU - Lok, M.C.

AU - de Wolf, H.K.

AU - Hennink, W.E.

AU - Feijen, J.

AU - Engbersen, J.F.J.

N1 - Conference code: 10

PY - 2008

Y1 - 2008

N2 - Bioreducible poly(amido amine)s (SS-PAAs) with different groups in the side chain were evaluated for gene delivery to ovarian cancer cells, both in vitro and in vivo after intraperitoneal administration in mice bearing an ovarian cancer xenograft. Polyplexes of SS-PAAs with e.g. hydroxybutyl or hydroxypentyl side groups induce much higher transfection in vitro than polyplexes of branched pEI (25 kDa) as a positive control. The in vivo transfection efficiency of polyplexes of SS-PAA with hydroxybutyl side groups is similar to that of linear pEI (22 kDa).

AB - Bioreducible poly(amido amine)s (SS-PAAs) with different groups in the side chain were evaluated for gene delivery to ovarian cancer cells, both in vitro and in vivo after intraperitoneal administration in mice bearing an ovarian cancer xenograft. Polyplexes of SS-PAAs with e.g. hydroxybutyl or hydroxypentyl side groups induce much higher transfection in vitro than polyplexes of branched pEI (25 kDa) as a positive control. The in vivo transfection efficiency of polyplexes of SS-PAA with hydroxybutyl side groups is similar to that of linear pEI (22 kDa).

U2 - 10.1016/j.jconrel.2008.09.045

DO - 10.1016/j.jconrel.2008.09.045

M3 - Meeting Abstract

SN - 0168-3659

VL - 132

SP - e9-e10

JO - Journal of controlled release

JF - Journal of controlled release

IS - 3

T2 - 10th European Symposium on Controlled Drug Delivery, ESCDD 2008

Y2 - 2 April 2008 through 4 April 2008

ER -

Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells

Abstract

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Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells

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