Bioreducible poly(amido amine)s for non-viral gene delivery

Chao Lin

    Research output: ThesisPhD Thesis - Research UT, graduation UT

    22 Downloads (Pure)

    Abstract

    This thesis describes the design and development of bioreducible poly(amido amine)s as non-viral vectors for gene delivery in vitro and in vivo. The structural influences of these polymers on their physico-chemical properties and gene delivery properties, transfection capability and cytotoxicity in vitro are discussed in detail. Preliminary results on in vivo gene delivery to ovarian cancer cells with the bioreducible poly(amido amine)s are also described.
    Original languageEnglish
    Awarding Institution
    • University of Twente
    Supervisors/Advisors
    • Engbersen, J.F.J., Supervisor
    • Feijen, J., Supervisor
    Award date25 Apr 2008
    Place of PublicationEnschede
    Publisher
    Print ISBNs978-90-365-2651-7
    Publication statusPublished - 25 Mar 2008

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    Keywords

    • IR-59046

    Cite this

    Lin, C. (2008). Bioreducible poly(amido amine)s for non-viral gene delivery. Enschede: University of Twente.