Bioreducible poly(amidoamine)s with charge-reversel properties for intracellular protein delivery

G.M.J.P.C. Coué, Johannes F.J. Engbersen

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

An effective intracellular protein delivery system was developed using bioreducible disulfide-containing poly(amidoamine)s with negatively charged citraconic side groups that can give charge-reversal upon pH decrease. These water-soluble and linear polymers efficiently self-assemble with proteins into nanocomplexes by charge attraction. Intracellular-mimicking protein release from the particles is triggered by the reduction of polymer disulfide linkages, causing polymer degradation, and inversion of protein-polymer interaction at endosomal pH due to the charge-reversal of the citraconic side group.
Original languageEnglish
Title of host publicationProceedings 11th european symposium on controlled drug delivery
EditorsW.E. Hennink, J.F.J. Engbersen
PublisherElsevier
Pagese9-e11
DOIs
Publication statusPublished - 7 Apr 2010
Event11th European Symposium on Controlled Drug Delivery, ESCDD 2010 - Hotel Zuiderduin, Egmond aan Zee (NL), Netherlands
Duration: 7 Apr 20109 Apr 2010
Conference number: 11

Publication series

Name1
PublisherElsevier
Number1
Volume148
ISSN (Print)0168-3659
ISSN (Electronic)1873-4995

Conference

Conference11th European Symposium on Controlled Drug Delivery, ESCDD 2010
Abbreviated titleESCDD
CountryNetherlands
CityEgmond aan Zee (NL)
Period7/04/109/04/10

Keywords

  • METIS-274351
  • IR-80273

Fingerprint Dive into the research topics of 'Bioreducible poly(amidoamine)s with charge-reversel properties for intracellular protein delivery'. Together they form a unique fingerprint.

Cite this