Birth Weight Corrected for Gestational Age is Related to the Incidence of Down’s Syndrome Pregnancies

J.M. van Montfrans, P.S.M. Bakker, L.T.M. Rekers-Mombarg, M.M. Weissenbruch, C.B. Lambalk

Research output: Contribution to journalArticleAcademic

1 Citation (Scopus)

Abstract

Three recent studies reported that early depletion of the primordial follicle pool is likely to be an independent risk factor for Down’s syndrome pregnancies. The size of the primordial follicle pool at birth is determined by oogenesis and by the rate of follicle atresia during the intra uterine period. Since intra uterine growth retardation was reported to be associated with a significantly reduced primordial follicle pool at birth, we investigated the possibility of a relation between low birth weight for gestational age and the risk of a Down’s syndrome pregnancy. In a case control study, 95 women with a history of a Down’s syndrome pregnancy and 85 controls provided information on their own birth weight and length of gestation. Birth weight standard deviation scores, indicating the difference in birth weight from a reference group, were significantly lower in Down’s syndrome mothers than in controls. These findings illustrate that the risk of a Down’s syndrome pregnancy is related to a low birth weight corrected for gestational age, possibly by a causal relation between intra uterine growth retardation and the size of the primordial follicle pool.
Original languageUndefined
Pages (from-to)318-320
JournalTwin Research and Human Genetics
Volume4
Issue number5
DOIs
Publication statusPublished - Oct 2001

Keywords

  • IR-58541

Cite this

van Montfrans, J. M., Bakker, P. S. M., Rekers-Mombarg, L. T. M., Weissenbruch, M. M., & Lambalk, C. B. (2001). Birth Weight Corrected for Gestational Age is Related to the Incidence of Down’s Syndrome Pregnancies. Twin Research and Human Genetics , 4(5), 318-320. https://doi.org/10.1375/twin.4.5.318
van Montfrans, J.M. ; Bakker, P.S.M. ; Rekers-Mombarg, L.T.M. ; Weissenbruch, M.M. ; Lambalk, C.B. / Birth Weight Corrected for Gestational Age is Related to the Incidence of Down’s Syndrome Pregnancies. In: Twin Research and Human Genetics . 2001 ; Vol. 4, No. 5. pp. 318-320.
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abstract = "Three recent studies reported that early depletion of the primordial follicle pool is likely to be an independent risk factor for Down’s syndrome pregnancies. The size of the primordial follicle pool at birth is determined by oogenesis and by the rate of follicle atresia during the intra uterine period. Since intra uterine growth retardation was reported to be associated with a significantly reduced primordial follicle pool at birth, we investigated the possibility of a relation between low birth weight for gestational age and the risk of a Down’s syndrome pregnancy. In a case control study, 95 women with a history of a Down’s syndrome pregnancy and 85 controls provided information on their own birth weight and length of gestation. Birth weight standard deviation scores, indicating the difference in birth weight from a reference group, were significantly lower in Down’s syndrome mothers than in controls. These findings illustrate that the risk of a Down’s syndrome pregnancy is related to a low birth weight corrected for gestational age, possibly by a causal relation between intra uterine growth retardation and the size of the primordial follicle pool.",
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van Montfrans, JM, Bakker, PSM, Rekers-Mombarg, LTM, Weissenbruch, MM & Lambalk, CB 2001, 'Birth Weight Corrected for Gestational Age is Related to the Incidence of Down’s Syndrome Pregnancies', Twin Research and Human Genetics , vol. 4, no. 5, pp. 318-320. https://doi.org/10.1375/twin.4.5.318

Birth Weight Corrected for Gestational Age is Related to the Incidence of Down’s Syndrome Pregnancies. / van Montfrans, J.M.; Bakker, P.S.M.; Rekers-Mombarg, L.T.M.; Weissenbruch, M.M.; Lambalk, C.B.

In: Twin Research and Human Genetics , Vol. 4, No. 5, 10.2001, p. 318-320.

Research output: Contribution to journalArticleAcademic

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AU - Weissenbruch, M.M.

AU - Lambalk, C.B.

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