TY - JOUR
T1 - Birth Weight Corrected for Gestational Age is Related to the Incidence of Down’s Syndrome Pregnancies
AU - van Montfrans, J.M.
AU - Bakker, P.S.M.
AU - Rekers-Mombarg, L.T.M.
AU - Weissenbruch, M.M.
AU - Lambalk, C.B.
PY - 2001/10
Y1 - 2001/10
N2 - Three recent studies reported that early depletion of the primordial follicle pool is likely to be an independent risk factor for Down’s syndrome pregnancies. The size of the primordial follicle pool at birth is determined by oogenesis and by the rate of follicle atresia during the intra uterine period. Since intra uterine growth retardation was reported to be associated with a significantly reduced primordial follicle pool at birth, we investigated
the possibility of a relation between low birth weight for gestational age and the risk of a Down’s syndrome pregnancy. In a case control study, 95 women with a history of a Down’s syndrome pregnancy and 85 controls provided information on their own birth weight and length of gestation. Birth weight standard deviation scores, indicating the difference in birth weight from a reference group, were significantly lower in Down’s syndrome mothers than in controls. These findings illustrate that the risk of a Down’s syndrome pregnancy is related to a low birth weight corrected for gestational age, possibly by a causal relation between intra uterine growth retardation and the size of the primordial follicle pool.
AB - Three recent studies reported that early depletion of the primordial follicle pool is likely to be an independent risk factor for Down’s syndrome pregnancies. The size of the primordial follicle pool at birth is determined by oogenesis and by the rate of follicle atresia during the intra uterine period. Since intra uterine growth retardation was reported to be associated with a significantly reduced primordial follicle pool at birth, we investigated
the possibility of a relation between low birth weight for gestational age and the risk of a Down’s syndrome pregnancy. In a case control study, 95 women with a history of a Down’s syndrome pregnancy and 85 controls provided information on their own birth weight and length of gestation. Birth weight standard deviation scores, indicating the difference in birth weight from a reference group, were significantly lower in Down’s syndrome mothers than in controls. These findings illustrate that the risk of a Down’s syndrome pregnancy is related to a low birth weight corrected for gestational age, possibly by a causal relation between intra uterine growth retardation and the size of the primordial follicle pool.
KW - IR-58541
U2 - 10.1375/twin.4.5.318
DO - 10.1375/twin.4.5.318
M3 - Article
SN - 1832-4274
VL - 4
SP - 318
EP - 320
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
IS - 5
ER -