Bismuth salts and neurotoxicity: A randomised, single-blind and controlled study

L.A. Noach; J.L.A. Eekhof; L.J. Bour; F.E. Posthumus Meyjes; G.N.J. Tytgat; B.W. Ongerboer de Visser

doi:10.1177/096032719501400405

Bismuth salts and neurotoxicity: A randomised, single-blind and controlled study

L.A. Noach^*, J.L.A. Eekhof, L.J. Bour, F.E. Posthumus Meyjes, G.N.J. Tytgat, B.W. Ongerboer de Visser

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

The aim of this work was to investigate whether the nor mal use of colloidal bismuth subcitrate (CBS) and bismuth subnitrate (BSN) exhibits neurotoxic side-effects. A ran domised, single-blind controlled study was carried out in 66 patients with H. pylori associated gastritis. Patients were randomised to receive either amoxicillin (control group) for 4 weeks or BSN for 8 weeks or CBS for 8 weeks. Clinical and neurophysiological tests including elec troneurography (ENG) and spectral electroencephalogra phy (EEG) were performed before and after therapy. No clinically relevant changes were observed with clinical tests as well as with ENG and spectral EEG recordings within each group and between the groups. It was con cluded that the normal use of CBS and BSN does not exhibit clinical neurotoxicity.

Original language	English
Pages (from-to)	349-355
Number of pages	7
Journal	Human & Experimental Toxicology
Volume	14
Issue number	4
DOIs	https://doi.org/10.1177/096032719501400405
Publication status	Published - Apr 1995
Externally published	Yes

Keywords

Bismuth subnitrate
Bismuth toxicity
Colloidal bis muth subcitrate
Electroencephalography
Electroneurography
Neurotoxicity

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10.1177/096032719501400405

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title = "Bismuth salts and neurotoxicity: A randomised, single-blind and controlled study",

abstract = "The aim of this work was to investigate whether the nor mal use of colloidal bismuth subcitrate (CBS) and bismuth subnitrate (BSN) exhibits neurotoxic side-effects. A ran domised, single-blind controlled study was carried out in 66 patients with H. pylori associated gastritis. Patients were randomised to receive either amoxicillin (control group) for 4 weeks or BSN for 8 weeks or CBS for 8 weeks. Clinical and neurophysiological tests including elec troneurography (ENG) and spectral electroencephalogra phy (EEG) were performed before and after therapy. No clinically relevant changes were observed with clinical tests as well as with ENG and spectral EEG recordings within each group and between the groups. It was con cluded that the normal use of CBS and BSN does not exhibit clinical neurotoxicity.",

keywords = "Bismuth subnitrate, Bismuth toxicity, Colloidal bis muth subcitrate, Electroencephalography, Electroneurography, Neurotoxicity",

author = "L.A. Noach and J.L.A. Eekhof and L.J. Bour and {Posthumus Meyjes}, F.E. and G.N.J. Tytgat and {Ongerboer de Visser}, B.W.",

year = "1995",

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AU - Noach, L.A.

AU - Eekhof, J.L.A.

AU - Bour, L.J.

AU - Posthumus Meyjes, F.E.

AU - Tytgat, G.N.J.

AU - Ongerboer de Visser, B.W.

PY - 1995/4

Y1 - 1995/4

N2 - The aim of this work was to investigate whether the nor mal use of colloidal bismuth subcitrate (CBS) and bismuth subnitrate (BSN) exhibits neurotoxic side-effects. A ran domised, single-blind controlled study was carried out in 66 patients with H. pylori associated gastritis. Patients were randomised to receive either amoxicillin (control group) for 4 weeks or BSN for 8 weeks or CBS for 8 weeks. Clinical and neurophysiological tests including elec troneurography (ENG) and spectral electroencephalogra phy (EEG) were performed before and after therapy. No clinically relevant changes were observed with clinical tests as well as with ENG and spectral EEG recordings within each group and between the groups. It was con cluded that the normal use of CBS and BSN does not exhibit clinical neurotoxicity.

AB - The aim of this work was to investigate whether the nor mal use of colloidal bismuth subcitrate (CBS) and bismuth subnitrate (BSN) exhibits neurotoxic side-effects. A ran domised, single-blind controlled study was carried out in 66 patients with H. pylori associated gastritis. Patients were randomised to receive either amoxicillin (control group) for 4 weeks or BSN for 8 weeks or CBS for 8 weeks. Clinical and neurophysiological tests including elec troneurography (ENG) and spectral electroencephalogra phy (EEG) were performed before and after therapy. No clinically relevant changes were observed with clinical tests as well as with ENG and spectral EEG recordings within each group and between the groups. It was con cluded that the normal use of CBS and BSN does not exhibit clinical neurotoxicity.

KW - Bismuth subnitrate

KW - Bismuth toxicity

KW - Colloidal bis muth subcitrate

KW - Electroencephalography

KW - Electroneurography

KW - Neurotoxicity

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DO - 10.1177/096032719501400405

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JO - Human & Experimental Toxicology

JF - Human & Experimental Toxicology

IS - 4

ER -

Bismuth salts and neurotoxicity: A randomised, single-blind and controlled study

Abstract

Keywords

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