TY - JOUR
T1 - Biventricular pacemaker synchronization
T2 - A numerical cardiocirculatory model application to reproduce in vivo data
AU - Di Molfetta, Arianna
AU - De Lazzari, Claudio
AU - Ferrari, Gianfranco
AU - Moscariello, Flavio
AU - Aguzzi, Giulia
AU - Fresiello, Libera
AU - Darowski, Marek
AU - Trivella, Maria Giovanna
AU - Alessandri, Nicola
PY - 2010
Y1 - 2010
N2 - Cardiac Resynchronization Therapy (CRT) seems to be the most encouraging treatment to limit the damages of ventricular remodelling in patients with moderate-severe cardiac insufficiency. Mathematical modelling of the cardiovascular system is a tool potentially useful to understand how the Biventricular Pacemaker (BPM) must be synchronised during CRT. In this work a computer simulator reproduces clinical data measured, on different patients affected by asynchronous ventricular contraction, before and after CRT. Three patients, affected by asynchronous ventricular contraction, were monitored before and after biventricular stimulation through CRT. Measured and simulated data were compared. Results show that the software simulator can well reproduce in vivo data. Besides, simulated results from BPM together with drug therapy are in accordance with literature data. Numerical modelling could be a useful tool to optimize the BPM synchronization.
AB - Cardiac Resynchronization Therapy (CRT) seems to be the most encouraging treatment to limit the damages of ventricular remodelling in patients with moderate-severe cardiac insufficiency. Mathematical modelling of the cardiovascular system is a tool potentially useful to understand how the Biventricular Pacemaker (BPM) must be synchronised during CRT. In this work a computer simulator reproduces clinical data measured, on different patients affected by asynchronous ventricular contraction, before and after CRT. Three patients, affected by asynchronous ventricular contraction, were monitored before and after biventricular stimulation through CRT. Measured and simulated data were compared. Results show that the software simulator can well reproduce in vivo data. Besides, simulated results from BPM together with drug therapy are in accordance with literature data. Numerical modelling could be a useful tool to optimize the BPM synchronization.
KW - Circulatory system
KW - Computer simulation
KW - Coronary circulation
KW - Hemodynamics
KW - Left ventricle
UR - http://www.scopus.com/inward/record.url?scp=77949372669&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:77949372669
SN - 0208-5216
VL - 30
SP - 3
EP - 15
JO - Biocybernetics and biomedical engineering
JF - Biocybernetics and biomedical engineering
IS - 1
ER -