Abstract
Artificial vascularization of tissue has been a major barrier in the upscaling
of tissue engineering. Achieving angiogenesis from a pre-existing vessel in
a controlled manner is a possible solution to prevascularize tissue. Microfluidic
approaches do not allow yet the creation of a complex hierarchical
tissue construct that can be manipulated and removed from the creation
template.Thus the challenge is to simulate angiogenesis in a 1:1 scale.
We aim to assemble a blood vessel module that will include:
on-demand flow, through a tubular structure comprised of endothelial
cells, fibroblasts and smooth muscle cells suspended in a hydrogel
environment functionalized with growth factors.
of tissue engineering. Achieving angiogenesis from a pre-existing vessel in
a controlled manner is a possible solution to prevascularize tissue. Microfluidic
approaches do not allow yet the creation of a complex hierarchical
tissue construct that can be manipulated and removed from the creation
template.Thus the challenge is to simulate angiogenesis in a 1:1 scale.
We aim to assemble a blood vessel module that will include:
on-demand flow, through a tubular structure comprised of endothelial
cells, fibroblasts and smooth muscle cells suspended in a hydrogel
environment functionalized with growth factors.
| Original language | English |
|---|---|
| Publication status | Published - 28 Nov 2017 |
| Event | The Netherlands Society for Biomaterials and Tissue Engineering 26th Annual Meeting, 2017 - De Werelt Lunteren, Lunteren, Netherlands Duration: 29 Nov 2017 → 30 Nov 2017 Conference number: 26 http://nbte.nl/ |
Conference
| Conference | The Netherlands Society for Biomaterials and Tissue Engineering 26th Annual Meeting, 2017 |
|---|---|
| Abbreviated title | NBTE 2017 |
| Country/Territory | Netherlands |
| City | Lunteren |
| Period | 29/11/17 → 30/11/17 |
| Internet address |