Body weight-dependent Rubidium-82 activity results in constant image quality in myocardial perfusion imaging with PET

J. D. van Dijk, M. Dotinga, P.L. Jager, C. H. Slump, J.P. Ottervanger, M. Mouden, J.A. van Dalen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Clinical practice shows degrading image quality in heavier patients who undergo myocardial perfusion imaging (MPI) with Rubidium-82 (Rb-82) PET when using a fixed tracer activity. Our aim was to derive and validate a patient-specific activity protocol resulting in a constant image quality in PET MPI. Methods: We included 251 patients who underwent rest MPI with Rb-82 PET (Discovery 670, GE Healthcare). 132 patients were included retrospectively and were scanned using a fixed activity of 740 MBq. The total number of measured prompts was normalized to activity and correlated to body weight, mass per body length and body mass index to find the best predicting parameter. Next, a patient-specific activity was derived and subsequently validated in 119 additional patients. Image quality was scored by three experts on a four-point scale. Results: Both image quality and prompts decreased in heavier patients when using a fixed activity (p <.005). Body weight was used to derive a new activity formula: Activity = 8.3 MBq/kg. When applying this formula, both measured prompts and scored image quality became independent of body weight (p >.60). Conclusion: Administrating a Rb-82 activity that linearly depends on body weight resulted in a constant image quality across all patients and is recommended.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of nuclear cardiology
Early online date4 Sep 2019
DOIs
Publication statusE-pub ahead of print/First online - 4 Sep 2019

Fingerprint

Rubidium
Myocardial Perfusion Imaging
Body Weight
Body Mass Index
Delivery of Health Care

Keywords

  • UT-Hybrid-D
  • myocardial perfusion imaging
  • patient dose
  • Radiation dose reduction
  • rubidium-82
  • tracer activity

Cite this

van Dijk, J. D. ; Dotinga, M. ; Jager, P.L. ; Slump, C. H. ; Ottervanger, J.P. ; Mouden, M. ; van Dalen, J.A. / Body weight-dependent Rubidium-82 activity results in constant image quality in myocardial perfusion imaging with PET. In: Journal of nuclear cardiology. 2019 ; pp. 1-9.
@article{02c58493b6c5488a9e462c85d2dbfe8b,
title = "Body weight-dependent Rubidium-82 activity results in constant image quality in myocardial perfusion imaging with PET",
abstract = "Background: Clinical practice shows degrading image quality in heavier patients who undergo myocardial perfusion imaging (MPI) with Rubidium-82 (Rb-82) PET when using a fixed tracer activity. Our aim was to derive and validate a patient-specific activity protocol resulting in a constant image quality in PET MPI. Methods: We included 251 patients who underwent rest MPI with Rb-82 PET (Discovery 670, GE Healthcare). 132 patients were included retrospectively and were scanned using a fixed activity of 740 MBq. The total number of measured prompts was normalized to activity and correlated to body weight, mass per body length and body mass index to find the best predicting parameter. Next, a patient-specific activity was derived and subsequently validated in 119 additional patients. Image quality was scored by three experts on a four-point scale. Results: Both image quality and prompts decreased in heavier patients when using a fixed activity (p <.005). Body weight was used to derive a new activity formula: Activity = 8.3 MBq/kg. When applying this formula, both measured prompts and scored image quality became independent of body weight (p >.60). Conclusion: Administrating a Rb-82 activity that linearly depends on body weight resulted in a constant image quality across all patients and is recommended.",
keywords = "UT-Hybrid-D, myocardial perfusion imaging, patient dose, Radiation dose reduction, rubidium-82, tracer activity",
author = "{van Dijk}, {J. D.} and M. Dotinga and P.L. Jager and Slump, {C. H.} and J.P. Ottervanger and M. Mouden and {van Dalen}, J.A.",
note = "Springer deal",
year = "2019",
month = "9",
day = "4",
doi = "10.1007/s12350-019-01875-w",
language = "English",
pages = "1--9",
journal = "Journal of nuclear cardiology",
issn = "1071-3581",
publisher = "Springer",

}

Body weight-dependent Rubidium-82 activity results in constant image quality in myocardial perfusion imaging with PET. / van Dijk, J. D.; Dotinga, M.; Jager, P.L.; Slump, C. H.; Ottervanger, J.P.; Mouden, M.; van Dalen, J.A.

In: Journal of nuclear cardiology, 04.09.2019, p. 1-9.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Body weight-dependent Rubidium-82 activity results in constant image quality in myocardial perfusion imaging with PET

AU - van Dijk, J. D.

AU - Dotinga, M.

AU - Jager, P.L.

AU - Slump, C. H.

AU - Ottervanger, J.P.

AU - Mouden, M.

AU - van Dalen, J.A.

N1 - Springer deal

PY - 2019/9/4

Y1 - 2019/9/4

N2 - Background: Clinical practice shows degrading image quality in heavier patients who undergo myocardial perfusion imaging (MPI) with Rubidium-82 (Rb-82) PET when using a fixed tracer activity. Our aim was to derive and validate a patient-specific activity protocol resulting in a constant image quality in PET MPI. Methods: We included 251 patients who underwent rest MPI with Rb-82 PET (Discovery 670, GE Healthcare). 132 patients were included retrospectively and were scanned using a fixed activity of 740 MBq. The total number of measured prompts was normalized to activity and correlated to body weight, mass per body length and body mass index to find the best predicting parameter. Next, a patient-specific activity was derived and subsequently validated in 119 additional patients. Image quality was scored by three experts on a four-point scale. Results: Both image quality and prompts decreased in heavier patients when using a fixed activity (p <.005). Body weight was used to derive a new activity formula: Activity = 8.3 MBq/kg. When applying this formula, both measured prompts and scored image quality became independent of body weight (p >.60). Conclusion: Administrating a Rb-82 activity that linearly depends on body weight resulted in a constant image quality across all patients and is recommended.

AB - Background: Clinical practice shows degrading image quality in heavier patients who undergo myocardial perfusion imaging (MPI) with Rubidium-82 (Rb-82) PET when using a fixed tracer activity. Our aim was to derive and validate a patient-specific activity protocol resulting in a constant image quality in PET MPI. Methods: We included 251 patients who underwent rest MPI with Rb-82 PET (Discovery 670, GE Healthcare). 132 patients were included retrospectively and were scanned using a fixed activity of 740 MBq. The total number of measured prompts was normalized to activity and correlated to body weight, mass per body length and body mass index to find the best predicting parameter. Next, a patient-specific activity was derived and subsequently validated in 119 additional patients. Image quality was scored by three experts on a four-point scale. Results: Both image quality and prompts decreased in heavier patients when using a fixed activity (p <.005). Body weight was used to derive a new activity formula: Activity = 8.3 MBq/kg. When applying this formula, both measured prompts and scored image quality became independent of body weight (p >.60). Conclusion: Administrating a Rb-82 activity that linearly depends on body weight resulted in a constant image quality across all patients and is recommended.

KW - UT-Hybrid-D

KW - myocardial perfusion imaging

KW - patient dose

KW - Radiation dose reduction

KW - rubidium-82

KW - tracer activity

UR - http://www.scopus.com/inward/record.url?scp=85072190440&partnerID=8YFLogxK

U2 - 10.1007/s12350-019-01875-w

DO - 10.1007/s12350-019-01875-w

M3 - Article

SP - 1

EP - 9

JO - Journal of nuclear cardiology

JF - Journal of nuclear cardiology

SN - 1071-3581

ER -