Protein absorption, release of calcium and phosphate ions, surface calcification are the possible material mechanisms of calcium phosphate-induced ectopic bone formation. We studied the bone induction of non-microporus hydroxyapatite ceramic (HA-S), microporous HA (HA-R), microporous bioinert ceramics (TiO2 ceramic; Al2O3 ceramic; both incapable to release Ca/P ions and to get surface calcification). It was found that protein adsorption was material-specific. With almost no absorption of rhBMP-2, mirocporous TiO2 ceramic and Al2O3 ceramic induced bone formation. The results indicate that release of calcium and phosphate ions, surface calcification do not play a key role in osteoinduction, and surface microstructure induces bone formation may not be through protein adsorption.
|Pages (from-to)||01068-01072 and 01077|
|Journal||Gongneng Cailiao/Journal of Functional Materials|
|Publication status||Published - 30 Jan 2017|
- AlO ceramic
- Bone induction
- Surface micropore
- TiO ceramic