Bone induction of TiO2 and Al2O3 ceramic

Haitao Peng, Hong Li, Guoyu Lv, Joost D. De Bruijn, Yonggang Yan, Huipin Yuan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Protein absorption, release of calcium and phosphate ions, surface calcification are the possible material mechanisms of calcium phosphate-induced ectopic bone formation. We studied the bone induction of non-microporus hydroxyapatite ceramic (HA-S), microporous HA (HA-R), microporous bioinert ceramics (TiO2 ceramic; Al2O3 ceramic; both incapable to release Ca/P ions and to get surface calcification). It was found that protein adsorption was material-specific. With almost no absorption of rhBMP-2, mirocporous TiO2 ceramic and Al2O3 ceramic induced bone formation. The results indicate that release of calcium and phosphate ions, surface calcification do not play a key role in osteoinduction, and surface microstructure induces bone formation may not be through protein adsorption.

Original languageEnglish
Pages (from-to)01068-01072 and 01077
JournalGongneng Cailiao/Journal of Functional Materials
Issue number1
Publication statusPublished - 30 Jan 2017


  • AlO ceramic
  • Bone induction
  • Surface micropore
  • TiO ceramic

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