Both Poly(ethylene glycol) and Poly(methyl ethylene phosphate) Guide Oriented Adsorption of Specific Proteins

Christoph Bernhard, Steven J. Roeters, Kristin N. Bauer, Tobias Weidner, Mischa Bonn, Frederik R. Wurm, Grazia Gonella*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
10 Downloads (Pure)

Abstract

Developing new functional biomaterials requires the ability to simultaneously repel unwanted and guide wanted protein adsorption. Here, we systematically interrogate the factors determining the protein adsorption by comparing the behaviors of different polymeric surfaces, poly(ethylene glycol) and a poly(phosphoester), and five different natural proteins. Interestingly we observe that, at densities comparable to those used in nanocarrier functionalization, the same proteins are either adsorbed (fibrinogen, human serum albumin, and transferrin) or repelled (immunoglobulin G and lysozyme) by both polymers. However, when adsorption takes place, the specific surface dictates the amount and orientation of each protein.
Original languageEnglish
Pages (from-to)14092–14097
JournalLangmuir
Volume35
Issue number43
DOIs
Publication statusPublished - 29 Oct 2019
Externally publishedYes

Fingerprint

Dive into the research topics of 'Both Poly(ethylene glycol) and Poly(methyl ethylene phosphate) Guide Oriented Adsorption of Specific Proteins'. Together they form a unique fingerprint.

Cite this