Brain-on-a-Chip: A Human 3D Model for Clinical Application

Lorenzo Muzzi, Sergio Martinoia, Monica Frega

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The main goal of this research is to design, develop and implement an efficient protocol to generate 3D neural cultures derived from human induced Pluripotent Stem Cells (hiPSCs) coupled to Micro Electrode Arrays (MEA) in order to obtain an engineered and controlled brain-on-a-chip model. The use of patient specific iPSCs may offer novel insights into the pathophysiology of a large variety of disorders, including numerous neurodevelopmental and late-onset neurodegenerative conditions. With these in vitro patient specific models, we may have the possibility to test drugs and find ad hoc therapies in the direction of precision medicine.

Original languageEnglish
Title of host publicationpHealth 2019
Subtitle of host publicationProceedings of the 16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 10–12 June 2019, Genoa, Italy
EditorsBernd Blobel, Mauro Giacomini
Pages274-279
Number of pages6
Volume261
ISBN (Electronic)978-1-61499-975-1
DOIs
Publication statusPublished - 1 Aug 2019
Event16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 2019 - Villa Giustiniani Cambiaso, Genova, Italy
Duration: 10 Jun 201912 Jun 2019
Conference number: 16
https://phealth2019.unige.net/

Publication series

NameStudies in health technology and informatics
PublisherIOS Press
Volume261
ISSN (Print)0926-9630

Conference

Conference16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 2019
Abbreviated titlepHealth 2019
CountryItaly
CityGenova
Period10/06/1912/06/19
Internet address

Keywords

  • 3D brain model
  • Brian-on-a-chip
  • human induced pluripotent stem cells electrophysiology
  • micro electrodes array

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