Brain-on-a-Chip: A Human 3D Model for Clinical Application

Lorenzo Muzzi; Sergio Martinoia; Monica Frega

doi:10.3233/978-1-61499-975-1-274

Brain-on-a-Chip: A Human 3D Model for Clinical Application

Lorenzo Muzzi, Sergio Martinoia, Monica Frega

Clinical Neurophysiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

2 Citations (Scopus)

Abstract

The main goal of this research is to design, develop and implement an efficient protocol to generate 3D neural cultures derived from human induced Pluripotent Stem Cells (hiPSCs) coupled to Micro Electrode Arrays (MEA) in order to obtain an engineered and controlled brain-on-a-chip model. The use of patient specific iPSCs may offer novel insights into the pathophysiology of a large variety of disorders, including numerous neurodevelopmental and late-onset neurodegenerative conditions. With these in vitro patient specific models, we may have the possibility to test drugs and find ad hoc therapies in the direction of precision medicine.

Original language	English
Title of host publication	pHealth 2019
Subtitle of host publication	Proceedings of the 16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 10–12 June 2019, Genoa, Italy
Editors	Bernd Blobel, Mauro Giacomini
Pages	274-279
Number of pages	6
Volume	261
ISBN (Electronic)	978-1-61499-975-1
DOIs	https://doi.org/10.3233/978-1-61499-975-1-274
Publication status	Published - 1 Aug 2019
Event	16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 2019 - Villa Giustiniani Cambiaso, Genova, Italy Duration: 10 Jun 2019 → 12 Jun 2019 Conference number: 16 https://phealth2019.unige.net/

Publication series

Name	Studies in health technology and informatics
Publisher	IOS Press
Volume	261
ISSN (Print)	0926-9630

Conference

Conference	16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 2019
Abbreviated title	pHealth 2019
Country/Territory	Italy
City	Genova
Period	10/06/19 → 12/06/19
Internet address	https://phealth2019.unige.net/

Keywords

3D brain model
Brian-on-a-chip
human induced pluripotent stem cells electrophysiology
micro electrodes array

Access to Document

10.3233/978-1-61499-975-1-274

Cite this

Muzzi, L., Martinoia, S., & Frega, M. (2019). Brain-on-a-Chip: A Human 3D Model for Clinical Application. In B. Blobel, & M. Giacomini (Eds.), pHealth 2019 : Proceedings of the 16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 10–12 June 2019, Genoa, Italy (Vol. 261, pp. 274-279). (Studies in health technology and informatics; Vol. 261). https://doi.org/10.3233/978-1-61499-975-1-274

Muzzi, Lorenzo ; Martinoia, Sergio ; Frega, Monica. / Brain-on-a-Chip : A Human 3D Model for Clinical Application. pHealth 2019 : Proceedings of the 16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 10–12 June 2019, Genoa, Italy . editor / Bernd Blobel ; Mauro Giacomini. Vol. 261 2019. pp. 274-279 (Studies in health technology and informatics).

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abstract = "The main goal of this research is to design, develop and implement an efficient protocol to generate 3D neural cultures derived from human induced Pluripotent Stem Cells (hiPSCs) coupled to Micro Electrode Arrays (MEA) in order to obtain an engineered and controlled brain-on-a-chip model. The use of patient specific iPSCs may offer novel insights into the pathophysiology of a large variety of disorders, including numerous neurodevelopmental and late-onset neurodegenerative conditions. With these in vitro patient specific models, we may have the possibility to test drugs and find ad hoc therapies in the direction of precision medicine.",

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Muzzi, L, Martinoia, S & Frega, M 2019, Brain-on-a-Chip: A Human 3D Model for Clinical Application. in B Blobel & M Giacomini (eds), pHealth 2019 : Proceedings of the 16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 10–12 June 2019, Genoa, Italy . vol. 261, Studies in health technology and informatics, vol. 261, pp. 274-279, 16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 2019, Genova, Italy, 10/06/19. https://doi.org/10.3233/978-1-61499-975-1-274

Brain-on-a-Chip: A Human 3D Model for Clinical Application. / Muzzi, Lorenzo; Martinoia, Sergio; Frega, Monica.
pHealth 2019 : Proceedings of the 16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 10–12 June 2019, Genoa, Italy . ed. / Bernd Blobel; Mauro Giacomini. Vol. 261 2019. p. 274-279 (Studies in health technology and informatics; Vol. 261).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AB - The main goal of this research is to design, develop and implement an efficient protocol to generate 3D neural cultures derived from human induced Pluripotent Stem Cells (hiPSCs) coupled to Micro Electrode Arrays (MEA) in order to obtain an engineered and controlled brain-on-a-chip model. The use of patient specific iPSCs may offer novel insights into the pathophysiology of a large variety of disorders, including numerous neurodevelopmental and late-onset neurodegenerative conditions. With these in vitro patient specific models, we may have the possibility to test drugs and find ad hoc therapies in the direction of precision medicine.

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Muzzi L, Martinoia S, Frega M. Brain-on-a-Chip: A Human 3D Model for Clinical Application. In Blobel B, Giacomini M, editors, pHealth 2019 : Proceedings of the 16th International Conference on Wearable Micro and Nano Technologies for Personalized Health 10–12 June 2019, Genoa, Italy . Vol. 261. 2019. p. 274-279. (Studies in health technology and informatics). doi: 10.3233/978-1-61499-975-1-274

Brain-on-a-Chip: A Human 3D Model for Clinical Application

Abstract

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Keywords

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