Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma

Baris Imre; Elina Thibeau-Sutre; Jorieke Reimer; Kuan Kho; Jelmer M. Wolterink

doi:10.1007/978-3-031-72069-7_4

Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma

Baris Imre^*, Elina Thibeau-Sutre, Jorieke Reimer, Kuan Kho, Jelmer M. Wolterink

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

Chronic subdural hematoma (cSDH) is a common neurological condition characterized by the accumulation of blood between the brain and the dura mater. This accumulation of blood can exert pressure on the brain, potentially leading to fatal outcomes. Treatment options for cSDH are limited to invasive surgery or non-invasive management. Traditionally, the midline shift, hand-measured by experts from an ideal sagittal plane, and the hematoma volume have been the primary metrics for quantifying and analyzing cSDH. However, these approaches do not quantify the local 3D brain deformation caused by cSDH. We propose a novel method using anatomy-aware unsupervised diffeomorphic pseudo-healthy synthesis to generate brain deformation fields. The deformation fields derived from this process are utilized to extract biomarkers that quantify the shift in the brain due to cSDH. We use CT scans of 121 patients for training and validation of our method and find that our metrics allow the identification of patients who require surgery. Our results indicate that automatically obtained brain deformation fields might contain prognostic value for personalized cSDH treatment. Our implementation is available on: https://github.com/MIAGroupUT/Brain-Shift

Original language	English
Title of host publication	Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings
Editors	Marius George Linguraru, Qi Dou, Aasa Feragen, Stamatia Giannarou, Ben Glocker, Karim Lekadir, Julia A. Schnabel
Publisher	Springer
Pages	34-44
Number of pages	11
ISBN (Print)	9783031720680
DOIs	https://doi.org/10.1007/978-3-031-72069-7_4
Publication status	Published - 4 Oct 2024
Event	27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024 - Marrakesh, Morocco Duration: 6 Oct 2024 → 10 Oct 2024 Conference number: 27

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	15002 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024
Abbreviated title	MICCAI 2024
Country/Territory	Morocco
City	Marrakesh
Period	6/10/24 → 10/10/24

Keywords

2024 OA procedure
Chronic Subdural Hematoma
Diffeomorphic Image Registration
Pseudo-Healthy Brain Synthesis
Unsupervised Learning
Biomarker Extraction

Access to Document

10.1007/978-3-031-72069-7_4

978-3-031-72069-7_4Final published version, 2.92 MBLicence: Taverne

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Imre, B., Thibeau-Sutre, E., Reimer, J., Kho, K., & Wolterink, J. M. (2024). Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma. In M. G. Linguraru, Q. Dou, A. Feragen, S. Giannarou, B. Glocker, K. Lekadir, & J. A. Schnabel (Eds.), Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings (pp. 34-44). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 15002 LNCS). Springer. https://doi.org/10.1007/978-3-031-72069-7_4

Imre, Baris ; Thibeau-Sutre, Elina ; Reimer, Jorieke et al. / Brain-Shift : Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma. Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings. editor / Marius George Linguraru ; Qi Dou ; Aasa Feragen ; Stamatia Giannarou ; Ben Glocker ; Karim Lekadir ; Julia A. Schnabel. Springer, 2024. pp. 34-44 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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title = "Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma",

abstract = "Chronic subdural hematoma (cSDH) is a common neurological condition characterized by the accumulation of blood between the brain and the dura mater. This accumulation of blood can exert pressure on the brain, potentially leading to fatal outcomes. Treatment options for cSDH are limited to invasive surgery or non-invasive management. Traditionally, the midline shift, hand-measured by experts from an ideal sagittal plane, and the hematoma volume have been the primary metrics for quantifying and analyzing cSDH. However, these approaches do not quantify the local 3D brain deformation caused by cSDH. We propose a novel method using anatomy-aware unsupervised diffeomorphic pseudo-healthy synthesis to generate brain deformation fields. The deformation fields derived from this process are utilized to extract biomarkers that quantify the shift in the brain due to cSDH. We use CT scans of 121 patients for training and validation of our method and find that our metrics allow the identification of patients who require surgery. Our results indicate that automatically obtained brain deformation fields might contain prognostic value for personalized cSDH treatment. Our implementation is available on: https://github.com/MIAGroupUT/Brain-Shift",

keywords = "2024 OA procedure, Chronic Subdural Hematoma, Diffeomorphic Image Registration, Pseudo-Healthy Brain Synthesis, Unsupervised Learning, Biomarker Extraction",

author = "Baris Imre and Elina Thibeau-Sutre and Jorieke Reimer and Kuan Kho and Wolterink, \{Jelmer M.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.; 27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024, MICCAI 2024 ; Conference date: 06-10-2024 Through 10-10-2024",

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doi = "10.1007/978-3-031-72069-7\_4",

language = "English",

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series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

publisher = "Springer",

pages = "34--44",

editor = "Linguraru, \{Marius George\} and Qi Dou and Aasa Feragen and Stamatia Giannarou and Ben Glocker and Karim Lekadir and Schnabel, \{Julia A.\}",

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Imre, B, Thibeau-Sutre, E, Reimer, J, Kho, K & Wolterink, JM 2024, Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma. in MG Linguraru, Q Dou, A Feragen, S Giannarou, B Glocker, K Lekadir & JA Schnabel (eds), Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 15002 LNCS, Springer, pp. 34-44, 27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024, Marrakesh, Morocco, 6/10/24. https://doi.org/10.1007/978-3-031-72069-7_4

Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma. / Imre, Baris; Thibeau-Sutre, Elina; Reimer, Jorieke et al.
Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings. ed. / Marius George Linguraru; Qi Dou; Aasa Feragen; Stamatia Giannarou; Ben Glocker; Karim Lekadir; Julia A. Schnabel. Springer, 2024. p. 34-44 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 15002 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Brain-Shift

T2 - 27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024

AU - Imre, Baris

AU - Thibeau-Sutre, Elina

AU - Reimer, Jorieke

AU - Kho, Kuan

AU - Wolterink, Jelmer M.

N1 - Conference code: 27

PY - 2024/10/4

Y1 - 2024/10/4

N2 - Chronic subdural hematoma (cSDH) is a common neurological condition characterized by the accumulation of blood between the brain and the dura mater. This accumulation of blood can exert pressure on the brain, potentially leading to fatal outcomes. Treatment options for cSDH are limited to invasive surgery or non-invasive management. Traditionally, the midline shift, hand-measured by experts from an ideal sagittal plane, and the hematoma volume have been the primary metrics for quantifying and analyzing cSDH. However, these approaches do not quantify the local 3D brain deformation caused by cSDH. We propose a novel method using anatomy-aware unsupervised diffeomorphic pseudo-healthy synthesis to generate brain deformation fields. The deformation fields derived from this process are utilized to extract biomarkers that quantify the shift in the brain due to cSDH. We use CT scans of 121 patients for training and validation of our method and find that our metrics allow the identification of patients who require surgery. Our results indicate that automatically obtained brain deformation fields might contain prognostic value for personalized cSDH treatment. Our implementation is available on: https://github.com/MIAGroupUT/Brain-Shift

AB - Chronic subdural hematoma (cSDH) is a common neurological condition characterized by the accumulation of blood between the brain and the dura mater. This accumulation of blood can exert pressure on the brain, potentially leading to fatal outcomes. Treatment options for cSDH are limited to invasive surgery or non-invasive management. Traditionally, the midline shift, hand-measured by experts from an ideal sagittal plane, and the hematoma volume have been the primary metrics for quantifying and analyzing cSDH. However, these approaches do not quantify the local 3D brain deformation caused by cSDH. We propose a novel method using anatomy-aware unsupervised diffeomorphic pseudo-healthy synthesis to generate brain deformation fields. The deformation fields derived from this process are utilized to extract biomarkers that quantify the shift in the brain due to cSDH. We use CT scans of 121 patients for training and validation of our method and find that our metrics allow the identification of patients who require surgery. Our results indicate that automatically obtained brain deformation fields might contain prognostic value for personalized cSDH treatment. Our implementation is available on: https://github.com/MIAGroupUT/Brain-Shift

KW - 2024 OA procedure

KW - Chronic Subdural Hematoma

KW - Diffeomorphic Image Registration

KW - Pseudo-Healthy Brain Synthesis

KW - Unsupervised Learning

KW - Biomarker Extraction

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U2 - 10.1007/978-3-031-72069-7_4

DO - 10.1007/978-3-031-72069-7_4

M3 - Conference contribution

AN - SCOPUS:85206449335

SN - 9783031720680

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 34

EP - 44

BT - Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings

A2 - Linguraru, Marius George

A2 - Dou, Qi

A2 - Feragen, Aasa

A2 - Giannarou, Stamatia

A2 - Glocker, Ben

A2 - Lekadir, Karim

A2 - Schnabel, Julia A.

PB - Springer

Y2 - 6 October 2024 through 10 October 2024

ER -

Imre B, Thibeau-Sutre E, Reimer J, Kho K , Wolterink JM. Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma. In Linguraru MG, Dou Q, Feragen A, Giannarou S, Glocker B, Lekadir K, Schnabel JA, editors, Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings. Springer. 2024. p. 34-44. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-031-72069-7_4

Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma

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Brain-Shift: Unsupervised Pseudo-Healthy Brain Synthesis for Novel Biomarker Extraction in Chronic Subdural Hematoma

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