Breast-conserving therapy in older patients with breast cancer over three decades: progress or stagnation

Jan J. Jobsen* (Corresponding Author), Judith G. Middelburg, Job van der Palen, Sietske Riemersma, Ester Siemerink, Henk Struikmans, Sabine Siesling

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2 Downloads (Pure)

Abstract

Background: The aim of this study was to analyze the distant metastases-free survival (DMFS), and disease-specific survival (DSS) after breast-conserving therapy (BCT) in older patients with breast cancer in a large, population-based, single-center cohort study with long-term follow-up.

Material and Methods: Analyses were based on 1,425 women aged 65 years and older with breast cancer treated with BCT. Patients were divided in three age categories: 65 – 70 years, 71 – 75 years, and >75 years. The study period extended over 30 years, divided in three decades. Multivariate survival analysis was carried out using Cox regression analysis.

Results: The two youngest age categories showed significant improvements over time in 12-year DMFS and DSS. For women aged 65 – 70 years, this improvement was noted in stage I and stage II disease, while for women aged 71 – 75 years this was mainly in stage II tumors. Women >75 years of age did not show any improvement over time, regardless of stage.

Conclusion: Among older Dutch women with breast cancer, outcomes with regard to DMFS and DSS after BCT differ between various age categories, showing the least gain in the very old.

Original languageEnglish
Pages (from-to)330-336
JournalJournal of geriatric oncology
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Mar 2019

Fingerprint

Breast
Breast Neoplasms
Disease-Free Survival
Neoplasm Metastasis
Survival
Therapeutics
Survival Analysis
Cohort Studies
Multivariate Analysis
Regression Analysis
Population
Neoplasms

Keywords

  • UT-Hybrid-D
  • Breast-conserving therapy
  • Cohort study
  • Older adults
  • Survival analyses
  • Breast neoplasms

Cite this

Jobsen, Jan J. ; Middelburg, Judith G. ; van der Palen, Job ; Riemersma, Sietske ; Siemerink, Ester ; Struikmans, Henk ; Siesling, Sabine. / Breast-conserving therapy in older patients with breast cancer over three decades : progress or stagnation. In: Journal of geriatric oncology. 2019 ; Vol. 10, No. 2. pp. 330-336.
@article{a99b64ce8b854251be68b30e832fc5fb,
title = "Breast-conserving therapy in older patients with breast cancer over three decades: progress or stagnation",
abstract = "Background: The aim of this study was to analyze the distant metastases-free survival (DMFS), and disease-specific survival (DSS) after breast-conserving therapy (BCT) in older patients with breast cancer in a large, population-based, single-center cohort study with long-term follow-up.Material and Methods: Analyses were based on 1,425 women aged 65 years and older with breast cancer treated with BCT. Patients were divided in three age categories: 65 – 70 years, 71 – 75 years, and >75 years. The study period extended over 30 years, divided in three decades. Multivariate survival analysis was carried out using Cox regression analysis.Results: The two youngest age categories showed significant improvements over time in 12-year DMFS and DSS. For women aged 65 – 70 years, this improvement was noted in stage I and stage II disease, while for women aged 71 – 75 years this was mainly in stage II tumors. Women >75 years of age did not show any improvement over time, regardless of stage.Conclusion: Among older Dutch women with breast cancer, outcomes with regard to DMFS and DSS after BCT differ between various age categories, showing the least gain in the very old.",
keywords = "UT-Hybrid-D, Breast-conserving therapy, Cohort study, Older adults, Survival analyses, Breast neoplasms",
author = "Jobsen, {Jan J.} and Middelburg, {Judith G.} and {van der Palen}, Job and Sietske Riemersma and Ester Siemerink and Henk Struikmans and Sabine Siesling",
note = "Elsevier deal",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.jgo.2018.08.007",
language = "English",
volume = "10",
pages = "330--336",
journal = "Journal of geriatric oncology",
issn = "1879-4068",
publisher = "Elsevier",
number = "2",

}

Breast-conserving therapy in older patients with breast cancer over three decades : progress or stagnation. / Jobsen, Jan J. (Corresponding Author); Middelburg, Judith G.; van der Palen, Job; Riemersma, Sietske; Siemerink, Ester; Struikmans, Henk; Siesling, Sabine.

In: Journal of geriatric oncology, Vol. 10, No. 2, 01.03.2019, p. 330-336.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Breast-conserving therapy in older patients with breast cancer over three decades

T2 - progress or stagnation

AU - Jobsen, Jan J.

AU - Middelburg, Judith G.

AU - van der Palen, Job

AU - Riemersma, Sietske

AU - Siemerink, Ester

AU - Struikmans, Henk

AU - Siesling, Sabine

N1 - Elsevier deal

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: The aim of this study was to analyze the distant metastases-free survival (DMFS), and disease-specific survival (DSS) after breast-conserving therapy (BCT) in older patients with breast cancer in a large, population-based, single-center cohort study with long-term follow-up.Material and Methods: Analyses were based on 1,425 women aged 65 years and older with breast cancer treated with BCT. Patients were divided in three age categories: 65 – 70 years, 71 – 75 years, and >75 years. The study period extended over 30 years, divided in three decades. Multivariate survival analysis was carried out using Cox regression analysis.Results: The two youngest age categories showed significant improvements over time in 12-year DMFS and DSS. For women aged 65 – 70 years, this improvement was noted in stage I and stage II disease, while for women aged 71 – 75 years this was mainly in stage II tumors. Women >75 years of age did not show any improvement over time, regardless of stage.Conclusion: Among older Dutch women with breast cancer, outcomes with regard to DMFS and DSS after BCT differ between various age categories, showing the least gain in the very old.

AB - Background: The aim of this study was to analyze the distant metastases-free survival (DMFS), and disease-specific survival (DSS) after breast-conserving therapy (BCT) in older patients with breast cancer in a large, population-based, single-center cohort study with long-term follow-up.Material and Methods: Analyses were based on 1,425 women aged 65 years and older with breast cancer treated with BCT. Patients were divided in three age categories: 65 – 70 years, 71 – 75 years, and >75 years. The study period extended over 30 years, divided in three decades. Multivariate survival analysis was carried out using Cox regression analysis.Results: The two youngest age categories showed significant improvements over time in 12-year DMFS and DSS. For women aged 65 – 70 years, this improvement was noted in stage I and stage II disease, while for women aged 71 – 75 years this was mainly in stage II tumors. Women >75 years of age did not show any improvement over time, regardless of stage.Conclusion: Among older Dutch women with breast cancer, outcomes with regard to DMFS and DSS after BCT differ between various age categories, showing the least gain in the very old.

KW - UT-Hybrid-D

KW - Breast-conserving therapy

KW - Cohort study

KW - Older adults

KW - Survival analyses

KW - Breast neoplasms

UR - http://www.scopus.com/inward/record.url?scp=85051624741&partnerID=8YFLogxK

U2 - 10.1016/j.jgo.2018.08.007

DO - 10.1016/j.jgo.2018.08.007

M3 - Article

AN - SCOPUS:85051624741

VL - 10

SP - 330

EP - 336

JO - Journal of geriatric oncology

JF - Journal of geriatric oncology

SN - 1879-4068

IS - 2

ER -