TY - JOUR
T1 - Breast-conserving therapy in older patients with breast cancer over three decades
T2 - progress or stagnation
AU - Jobsen, Jan J.
AU - Middelburg, Judith G.
AU - van der Palen, Job
AU - Riemersma, Sietske
AU - Siemerink, Ester
AU - Struikmans, Henk
AU - Siesling, Sabine
N1 - Elsevier deal
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Background: The aim of this study was to analyze the distant metastases-free survival (DMFS), and disease-specific survival (DSS) after breast-conserving therapy (BCT) in older patients with breast cancer in a large, population-based, single-center cohort study with long-term follow-up.Material and Methods: Analyses were based on 1,425 women aged 65 years and older with breast cancer treated with BCT. Patients were divided in three age categories: 65 – 70 years, 71 – 75 years, and >75 years. The study period extended over 30 years, divided in three decades. Multivariate survival analysis was carried out using Cox regression analysis.Results: The two youngest age categories showed significant improvements over time in 12-year DMFS and DSS. For women aged 65 – 70 years, this improvement was noted in stage I and stage II disease, while for women aged 71 – 75 years this was mainly in stage II tumors. Women >75 years of age did not show any improvement over time, regardless of stage.Conclusion: Among older Dutch women with breast cancer, outcomes with regard to DMFS and DSS after BCT differ between various age categories, showing the least gain in the very old.
AB - Background: The aim of this study was to analyze the distant metastases-free survival (DMFS), and disease-specific survival (DSS) after breast-conserving therapy (BCT) in older patients with breast cancer in a large, population-based, single-center cohort study with long-term follow-up.Material and Methods: Analyses were based on 1,425 women aged 65 years and older with breast cancer treated with BCT. Patients were divided in three age categories: 65 – 70 years, 71 – 75 years, and >75 years. The study period extended over 30 years, divided in three decades. Multivariate survival analysis was carried out using Cox regression analysis.Results: The two youngest age categories showed significant improvements over time in 12-year DMFS and DSS. For women aged 65 – 70 years, this improvement was noted in stage I and stage II disease, while for women aged 71 – 75 years this was mainly in stage II tumors. Women >75 years of age did not show any improvement over time, regardless of stage.Conclusion: Among older Dutch women with breast cancer, outcomes with regard to DMFS and DSS after BCT differ between various age categories, showing the least gain in the very old.
KW - UT-Hybrid-D
KW - Breast-conserving therapy
KW - Cohort study
KW - Older adults
KW - Survival analyses
KW - Breast neoplasms
KW - 22/4 OA procedure
UR - http://www.scopus.com/inward/record.url?scp=85051624741&partnerID=8YFLogxK
U2 - 10.1016/j.jgo.2018.08.007
DO - 10.1016/j.jgo.2018.08.007
M3 - Article
AN - SCOPUS:85051624741
VL - 10
SP - 330
EP - 336
JO - Journal of geriatric oncology
JF - Journal of geriatric oncology
SN - 1879-4068
IS - 2
ER -