Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

M. Reza Nejadnik, X. Yang, T. Mimura, Zeinab Tahmasebi Birgani, Pamela Habibovic, K. Itatani, J.A. Jansen, J. Hilborn, D. Ossipov, A.G. Mikos, S.C.G. Leeuwenburgh

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg2+ and Ca2+. More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.
Original languageEnglish
Pages (from-to)1308-1313
JournalMacromolecular bioscience
Volume13
Issue number10
DOIs
Publication statusPublished - 16 Jul 2013

Keywords

  • METIS-296909
  • IR-86619

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