Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

M. Reza Nejadnik; X. Yang; T. Mimura; Zeinab Tahmasebi Birgani; Pamela Habibovic; K. Itatani; J.A. Jansen; J. Hilborn; D. Ossipov; A.G. Mikos; S.C.G. Leeuwenburgh

doi:10.1002/mabi.201300117

Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

M. Reza Nejadnik
, X. Yang
, T. Mimura
, Zeinab Tahmasebi Birgani
, Pamela Habibovic
, K. Itatani
, J.A. Jansen
, J. Hilborn
, D. Ossipov
, A.G. Mikos
, S.C.G. Leeuwenburgh

Faculty of Science and Technology

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

5 Downloads (Pure)

Abstract

This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg2+ and Ca2+. More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.

Original language	English
Pages (from-to)	1308-1313
Journal	Macromolecular bioscience
Volume	13
Issue number	10
DOIs	https://doi.org/10.1002/mabi.201300117
Publication status	Published - 16 Jul 2013

Keywords

METIS-296909
IR-86619

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10.1002/mabi.201300117

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Reza Nejadnik, M., Yang, X., Mimura, T., Tahmasebi Birgani, Z., Habibovic, P., Itatani, K., Jansen, J. A., Hilborn, J., Ossipov, D., Mikos, A. G., & Leeuwenburgh, S. C. G. (2013). Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels. Macromolecular bioscience, 13(10), 1308-1313. https://doi.org/10.1002/mabi.201300117

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abstract = "This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg2+ and Ca2+. More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.",

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AU - Reza Nejadnik, M.

AU - Yang, X.

AU - Mimura, T.

AU - Tahmasebi Birgani, Zeinab

AU - Habibovic, Pamela

AU - Itatani, K.

AU - Jansen, J.A.

AU - Hilborn, J.

AU - Ossipov, D.

AU - Mikos, A.G.

AU - Leeuwenburgh, S.C.G.

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AB - This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg2+ and Ca2+. More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.

KW - METIS-296909

KW - IR-86619

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DO - 10.1002/mabi.201300117

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JF - Macromolecular bioscience

IS - 10

ER -

Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

Abstract

Keywords

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