Calcium model for mammalian skeletal muscle

W. Wallinga, H.B.K. Boom, R.J. Heijink, G.H. van der Vliet

    Research output: Contribution to journalArticleAcademic

    7 Citations (Scopus)
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    Abstract

    A model is presented describing quantitatively the events between excitation and force development in skeletal muscle. It consists of a calcium mediated activation model (c.m.a.m.) in series with a force generator model (f.g.m.). The c.m.a.m. was based on intracellular processes such as cisternal Ca-release, Ca-troponin interaction and Ca-uptake by SR. Ca-troponin complex concentration is an output of the c.m.a.m. and input of the f.g.m., the latter being a simplified actinmyosin cross-bridge model. Simulated and measured forces were compared for the rat slow (soleus) muscle. With the present structure and parameter values there is reasonable agreement between simulated and measured forces for single- and double-pulse responses. The parameters of the f.g.m. mainly determine the rising phase of the twitch since the Ca-release is brief and the binding of Ca to troponin is fast. In relaxation the Ca-troponin interaction and the Ca transporting ATPase parameters are also important. The behaviour of the muscle after a second action potential depends strongly on the level of Ca occupancy for both the troponin and Ca transporting ATPase.
    Original languageUndefined
    Pages (from-to)734-748
    JournalMedical & biological engineering & computing
    Volume19
    Issue number6
    DOIs
    Publication statusPublished - 1981

    Keywords

    • Calcium activation
    • Rat skeletal muscle
    • Force development
    • IR-85654
    • Muscle model
    • Excitation-contraction coupling

    Cite this

    Wallinga, W., Boom, H. B. K., Heijink, R. J., & van der Vliet, G. H. (1981). Calcium model for mammalian skeletal muscle. Medical & biological engineering & computing, 19(6), 734-748. https://doi.org/10.1007/BF02441335
    Wallinga, W. ; Boom, H.B.K. ; Heijink, R.J. ; van der Vliet, G.H. / Calcium model for mammalian skeletal muscle. In: Medical & biological engineering & computing. 1981 ; Vol. 19, No. 6. pp. 734-748.
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    title = "Calcium model for mammalian skeletal muscle",
    abstract = "A model is presented describing quantitatively the events between excitation and force development in skeletal muscle. It consists of a calcium mediated activation model (c.m.a.m.) in series with a force generator model (f.g.m.). The c.m.a.m. was based on intracellular processes such as cisternal Ca-release, Ca-troponin interaction and Ca-uptake by SR. Ca-troponin complex concentration is an output of the c.m.a.m. and input of the f.g.m., the latter being a simplified actinmyosin cross-bridge model. Simulated and measured forces were compared for the rat slow (soleus) muscle. With the present structure and parameter values there is reasonable agreement between simulated and measured forces for single- and double-pulse responses. The parameters of the f.g.m. mainly determine the rising phase of the twitch since the Ca-release is brief and the binding of Ca to troponin is fast. In relaxation the Ca-troponin interaction and the Ca transporting ATPase parameters are also important. The behaviour of the muscle after a second action potential depends strongly on the level of Ca occupancy for both the troponin and Ca transporting ATPase.",
    keywords = "Calcium activation, Rat skeletal muscle, Force development, IR-85654, Muscle model, Excitation-contraction coupling",
    author = "W. Wallinga and H.B.K. Boom and R.J. Heijink and {van der Vliet}, G.H.",
    year = "1981",
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    Wallinga, W, Boom, HBK, Heijink, RJ & van der Vliet, GH 1981, 'Calcium model for mammalian skeletal muscle', Medical & biological engineering & computing, vol. 19, no. 6, pp. 734-748. https://doi.org/10.1007/BF02441335

    Calcium model for mammalian skeletal muscle. / Wallinga, W.; Boom, H.B.K.; Heijink, R.J.; van der Vliet, G.H.

    In: Medical & biological engineering & computing, Vol. 19, No. 6, 1981, p. 734-748.

    Research output: Contribution to journalArticleAcademic

    TY - JOUR

    T1 - Calcium model for mammalian skeletal muscle

    AU - Wallinga, W.

    AU - Boom, H.B.K.

    AU - Heijink, R.J.

    AU - van der Vliet, G.H.

    PY - 1981

    Y1 - 1981

    N2 - A model is presented describing quantitatively the events between excitation and force development in skeletal muscle. It consists of a calcium mediated activation model (c.m.a.m.) in series with a force generator model (f.g.m.). The c.m.a.m. was based on intracellular processes such as cisternal Ca-release, Ca-troponin interaction and Ca-uptake by SR. Ca-troponin complex concentration is an output of the c.m.a.m. and input of the f.g.m., the latter being a simplified actinmyosin cross-bridge model. Simulated and measured forces were compared for the rat slow (soleus) muscle. With the present structure and parameter values there is reasonable agreement between simulated and measured forces for single- and double-pulse responses. The parameters of the f.g.m. mainly determine the rising phase of the twitch since the Ca-release is brief and the binding of Ca to troponin is fast. In relaxation the Ca-troponin interaction and the Ca transporting ATPase parameters are also important. The behaviour of the muscle after a second action potential depends strongly on the level of Ca occupancy for both the troponin and Ca transporting ATPase.

    AB - A model is presented describing quantitatively the events between excitation and force development in skeletal muscle. It consists of a calcium mediated activation model (c.m.a.m.) in series with a force generator model (f.g.m.). The c.m.a.m. was based on intracellular processes such as cisternal Ca-release, Ca-troponin interaction and Ca-uptake by SR. Ca-troponin complex concentration is an output of the c.m.a.m. and input of the f.g.m., the latter being a simplified actinmyosin cross-bridge model. Simulated and measured forces were compared for the rat slow (soleus) muscle. With the present structure and parameter values there is reasonable agreement between simulated and measured forces for single- and double-pulse responses. The parameters of the f.g.m. mainly determine the rising phase of the twitch since the Ca-release is brief and the binding of Ca to troponin is fast. In relaxation the Ca-troponin interaction and the Ca transporting ATPase parameters are also important. The behaviour of the muscle after a second action potential depends strongly on the level of Ca occupancy for both the troponin and Ca transporting ATPase.

    KW - Calcium activation

    KW - Rat skeletal muscle

    KW - Force development

    KW - IR-85654

    KW - Muscle model

    KW - Excitation-contraction coupling

    U2 - 10.1007/BF02441335

    DO - 10.1007/BF02441335

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