Calcium model for mammalian skeletal muscle

W. Wallinga, H.B.K. Boom, R.J. Heijink, G.H. van der Vliet

Research output: Contribution to journalArticleAcademic

7 Citations (Scopus)
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Abstract

A model is presented describing quantitatively the events between excitation and force development in skeletal muscle. It consists of a calcium mediated activation model (c.m.a.m.) in series with a force generator model (f.g.m.). The c.m.a.m. was based on intracellular processes such as cisternal Ca-release, Ca-troponin interaction and Ca-uptake by SR. Ca-troponin complex concentration is an output of the c.m.a.m. and input of the f.g.m., the latter being a simplified actinmyosin cross-bridge model. Simulated and measured forces were compared for the rat slow (soleus) muscle. With the present structure and parameter values there is reasonable agreement between simulated and measured forces for single- and double-pulse responses. The parameters of the f.g.m. mainly determine the rising phase of the twitch since the Ca-release is brief and the binding of Ca to troponin is fast. In relaxation the Ca-troponin interaction and the Ca transporting ATPase parameters are also important. The behaviour of the muscle after a second action potential depends strongly on the level of Ca occupancy for both the troponin and Ca transporting ATPase.
Original languageUndefined
Pages (from-to)734-748
JournalMedical & biological engineering & computing
Volume19
Issue number6
DOIs
Publication statusPublished - 1981

Keywords

  • Calcium activation
  • Rat skeletal muscle
  • Force development
  • IR-85654
  • Muscle model
  • Excitation-contraction coupling

Cite this

Wallinga, W., Boom, H. B. K., Heijink, R. J., & van der Vliet, G. H. (1981). Calcium model for mammalian skeletal muscle. Medical & biological engineering & computing, 19(6), 734-748. https://doi.org/10.1007/BF02441335
Wallinga, W. ; Boom, H.B.K. ; Heijink, R.J. ; van der Vliet, G.H. / Calcium model for mammalian skeletal muscle. In: Medical & biological engineering & computing. 1981 ; Vol. 19, No. 6. pp. 734-748.
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Wallinga, W, Boom, HBK, Heijink, RJ & van der Vliet, GH 1981, 'Calcium model for mammalian skeletal muscle' Medical & biological engineering & computing, vol. 19, no. 6, pp. 734-748. https://doi.org/10.1007/BF02441335

Calcium model for mammalian skeletal muscle. / Wallinga, W.; Boom, H.B.K.; Heijink, R.J.; van der Vliet, G.H.

In: Medical & biological engineering & computing, Vol. 19, No. 6, 1981, p. 734-748.

Research output: Contribution to journalArticleAcademic

TY - JOUR

T1 - Calcium model for mammalian skeletal muscle

AU - Wallinga, W.

AU - Boom, H.B.K.

AU - Heijink, R.J.

AU - van der Vliet, G.H.

PY - 1981

Y1 - 1981

N2 - A model is presented describing quantitatively the events between excitation and force development in skeletal muscle. It consists of a calcium mediated activation model (c.m.a.m.) in series with a force generator model (f.g.m.). The c.m.a.m. was based on intracellular processes such as cisternal Ca-release, Ca-troponin interaction and Ca-uptake by SR. Ca-troponin complex concentration is an output of the c.m.a.m. and input of the f.g.m., the latter being a simplified actinmyosin cross-bridge model. Simulated and measured forces were compared for the rat slow (soleus) muscle. With the present structure and parameter values there is reasonable agreement between simulated and measured forces for single- and double-pulse responses. The parameters of the f.g.m. mainly determine the rising phase of the twitch since the Ca-release is brief and the binding of Ca to troponin is fast. In relaxation the Ca-troponin interaction and the Ca transporting ATPase parameters are also important. The behaviour of the muscle after a second action potential depends strongly on the level of Ca occupancy for both the troponin and Ca transporting ATPase.

AB - A model is presented describing quantitatively the events between excitation and force development in skeletal muscle. It consists of a calcium mediated activation model (c.m.a.m.) in series with a force generator model (f.g.m.). The c.m.a.m. was based on intracellular processes such as cisternal Ca-release, Ca-troponin interaction and Ca-uptake by SR. Ca-troponin complex concentration is an output of the c.m.a.m. and input of the f.g.m., the latter being a simplified actinmyosin cross-bridge model. Simulated and measured forces were compared for the rat slow (soleus) muscle. With the present structure and parameter values there is reasonable agreement between simulated and measured forces for single- and double-pulse responses. The parameters of the f.g.m. mainly determine the rising phase of the twitch since the Ca-release is brief and the binding of Ca to troponin is fast. In relaxation the Ca-troponin interaction and the Ca transporting ATPase parameters are also important. The behaviour of the muscle after a second action potential depends strongly on the level of Ca occupancy for both the troponin and Ca transporting ATPase.

KW - Calcium activation

KW - Rat skeletal muscle

KW - Force development

KW - IR-85654

KW - Muscle model

KW - Excitation-contraction coupling

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