Calcium signalling in secretory cells

L.A.C. Kallenberg

    Research output: Contribution to journalArticleAcademicpeer-review

    7 Citations (Scopus)

    Abstract

    Stimulation of secretory cells with muscarinic agonists leads to an increase in the intracellular Ca2+ concentration ([Ca2+]i), which activates protein secretion through exocytosis and causes closure of gap junctions between adjacent cells. In addition, the increase in [Ca2+]i activates three different kinds of ion channels: large K+ channels, Cl- channels and non-specific cation channels. The opening of those channels leads to an increase of [Na+] and a decrease of [Cl-] and [K+] in the cell. The two components that contribute to the increase in [Ca2+]i are calcium release from intracellular stores, localised in the endoplasmic reticulum and calcium influx through the plasma membrane. Several models for the regulation of [Ca2+]i have been proposed, including a recently suggested model whereby a distinct pathway involving arachidonic acid is added to the well-established capacitative model. Different hypotheses concerning coupling between the intra-cellular calcium stores and membrane channels co-exist. In addition to a historical overview, recent developments and future challenges are discussed in this review.
    Original languageEnglish
    Pages (from-to)385-390
    Number of pages6
    JournalArchives of physiology and biochemistry
    Volume108
    Issue number5
    DOIs
    Publication statusPublished - 2000

    Keywords

    • Calcium signalling
    • Muscarinic agonists
    • Secretion
    • Inositol 1, 4, 5-triphosphate
    • Capacitive model

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