Calix[4]arenes as building blocks for molecular receptors

Jan-Dirk van Loon, Jan-Dirk van Loon, Jan F. Heida, Willem Verboom, David Reinhoudt

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Abstract

Molecular receptors for organic molecules are described in which calix[4]arene is used as a molecular platform rather than for its cavity. This is illustrated by the synthesis of a receptor for barbiturates, a calix[4]arene in a cone conformation containing two diaminotriazine moieties at the upper rim. This receptor (9) forms a molecular cleft in which phenobarbital complexes by hydrogen bonding both triazine rings. The association constant K is 520 M 1, when the self-association of the barbiturate is taken into account.
Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalRecueil des travaux chimiques des Pays-Bas
Volume111
Issue number7-8
DOIs
Publication statusPublished - 1992

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