Can [18F]F-FDG PET/CT be used to assess the pre-operative extent of peritoneal carcinomatosis in patients with colorectal cancer?

Fortuné M.K. Elekonawo*, Bas Starremans, Sander Thomas Laurens, Andreas J.A. Bremers, Johannes H.W. de Wilt, Linda Heijmen, Lioe Fee de Geus-Oei

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: To evaluate whether PET/CT could be used to assess the extent of colorectal peritoneal metastases. Methods: All patients who underwent a PET/CT scan before a CRS-HIPEC procedure between January 1, 2010 and December 31, 2013 were retrospectively included (n = 35). Two nuclear medicine physicians (observer 1 and observer 2) separately reviewed the scans on intraperitoneal abnormalities. A simplified PCI was used to compare the extent of rPCI versus sPCI. Results: Included patients had a median age of 60.6 years. Histology of primary tumors were 51.5% adenocarcinomas, 37.1% mucinous adenocarcinoma, and 11.4% SRCC. Median sPCI was 9.5 (5.0–11.8) and median rPCI was 5.0 (3.0–7.0) for observer 1 and 4.0 (3.0–6.0) for observer 2 (p = 0.02 and p = 0.01, respectively). When compared to the surgical data, PET/CT showed a poor correlation for assessing the extent of PC for both adenocarcinoma (observer 1 rho – 0.17, p = 0.51 and observer 2 rho 0.13, p = 0.61) as well as mucinous carcinoma or SRCC (observer 1 rho 0.44, p = 0.08 and observer 2 rho 0.38, p = 0.14). Conclusion: PET/CT underestimates the extent of PC during surgery in both mucinous and non-mucinous CRC and is not recommended for intraperitoneal tumor scoring.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalAbdominal Radiology
Volume45
Issue number2
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • Colorectal cancer
  • HIPEC
  • Peritoneal carcinomatosis
  • [F]fluorodeoxyglucose positron emission tomography

Fingerprint Dive into the research topics of 'Can [<sup>18</sup>F]F-FDG PET/CT be used to assess the pre-operative extent of peritoneal carcinomatosis in patients with colorectal cancer?'. Together they form a unique fingerprint.

Cite this