Can vertebral density changes be explained by intervertebral disc degeneration?

Jasper Johan Homminga, R. Aquarius, Vera Elisabeth Bulsink, C.T.J. Jansen, Nicolaas Jacobus Joseph Verdonschot

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

One of the major problems facing the elderly spine is the occurrence of vertebral fractures due to low bone mass. Although typically attributed to osteoporosis, disc degeneration has also been suggested to play a role in vertebral fractures. Existing bone adaptation theories and simulations may explain the biomechanical pathway from a degenerated disc to an increased fracture risk. A finite element model of a lumbar segment was created and calibrated. Subsequently the disc properties were varied to represent either a healthy or degenerated disc and the resulting bone adaptation was simulated. Disc degeneration resulted in a shift of load from the nucleus to the annulus. The resulting bone adaptation led to a dramatically reduced density of the trabecular core and to an increased density in the vertebral walls. Degeneration of just the nucleus, and in particular the dehydration of the nucleus, resulted in most of this bone density change. Additional annulus degeneration had much less of an effect on the density values. The density decrease in the trabecular core as seen in this study matches clinical observations. Therefore, bone remodeling theories can assists in explaining the potential synergistic effects of disc degeneration and osteoporotis in the occurrence of vertebral fractures
Original languageEnglish
Pages (from-to)453-458
Number of pages6
JournalMedical engineering & physics
Volume34
Issue number4
DOIs
Publication statusPublished - 2012

Keywords

  • IR-84967
  • METIS-292636

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