Capacitive deionization on-chip as a method for microfluidic sample preparation

Susan Helena Roelofs, Bumjoo Kim, Jan C.T. Eijkel, Jongyoon Han, Albert van den Berg, Mathieu Odijk

    Research output: Contribution to journalArticleAcademicpeer-review

    11 Citations (Scopus)

    Abstract

    Desalination as a sample preparation step is essential for noise reduction and reproducibility of mass spectrometry measurements. A specific example is the analysis of proteins for medical research and clinical applications. Salts and buffers that are present in samples need to be removed before analysis to improve the signal-to-noise ratio. Capacitive deionization is an electrostatic desalination (CDI) technique which uses two porous electrodes facing each other to remove ions from a solution. Upon the application of a potential of 0.5 V ions migrate to the electrodes and are stored in the electrical double layer. In this article we demonstrate CDI on a chip, and desalinate a solution by the removal of 23% of Na+ and Cl- ions, while the concentration of a larger molecule (FITC-dextran) remains unchanged. For the first time impedance spectroscopy is introduced to monitor the salt concentration in situ in real-time in between the two desalination electrodes
    Original languageUndefined
    Pages (from-to)1458-1464
    Number of pages7
    JournalLab on a chip
    Volume15
    Issue number6
    DOIs
    Publication statusPublished - 2015

    Keywords

    • EWI-26008
    • IR-95880
    • METIS-312600

    Cite this

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    title = "Capacitive deionization on-chip as a method for microfluidic sample preparation",
    abstract = "Desalination as a sample preparation step is essential for noise reduction and reproducibility of mass spectrometry measurements. A specific example is the analysis of proteins for medical research and clinical applications. Salts and buffers that are present in samples need to be removed before analysis to improve the signal-to-noise ratio. Capacitive deionization is an electrostatic desalination (CDI) technique which uses two porous electrodes facing each other to remove ions from a solution. Upon the application of a potential of 0.5 V ions migrate to the electrodes and are stored in the electrical double layer. In this article we demonstrate CDI on a chip, and desalinate a solution by the removal of 23{\%} of Na+ and Cl- ions, while the concentration of a larger molecule (FITC-dextran) remains unchanged. For the first time impedance spectroscopy is introduced to monitor the salt concentration in situ in real-time in between the two desalination electrodes",
    keywords = "EWI-26008, IR-95880, METIS-312600",
    author = "Roelofs, {Susan Helena} and Bumjoo Kim and Eijkel, {Jan C.T.} and Jongyoon Han and {van den Berg}, Albert and Mathieu Odijk",
    note = "eemcs-eprint-26008",
    year = "2015",
    doi = "10.1039/c4lc01410c",
    language = "Undefined",
    volume = "15",
    pages = "1458--1464",
    journal = "Lab on a chip",
    issn = "1473-0197",
    publisher = "Royal Society of Chemistry",
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    Capacitive deionization on-chip as a method for microfluidic sample preparation. / Roelofs, Susan Helena; Kim, Bumjoo; Eijkel, Jan C.T.; Han, Jongyoon; van den Berg, Albert; Odijk, Mathieu.

    In: Lab on a chip, Vol. 15, No. 6, 2015, p. 1458-1464.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Capacitive deionization on-chip as a method for microfluidic sample preparation

    AU - Roelofs, Susan Helena

    AU - Kim, Bumjoo

    AU - Eijkel, Jan C.T.

    AU - Han, Jongyoon

    AU - van den Berg, Albert

    AU - Odijk, Mathieu

    N1 - eemcs-eprint-26008

    PY - 2015

    Y1 - 2015

    N2 - Desalination as a sample preparation step is essential for noise reduction and reproducibility of mass spectrometry measurements. A specific example is the analysis of proteins for medical research and clinical applications. Salts and buffers that are present in samples need to be removed before analysis to improve the signal-to-noise ratio. Capacitive deionization is an electrostatic desalination (CDI) technique which uses two porous electrodes facing each other to remove ions from a solution. Upon the application of a potential of 0.5 V ions migrate to the electrodes and are stored in the electrical double layer. In this article we demonstrate CDI on a chip, and desalinate a solution by the removal of 23% of Na+ and Cl- ions, while the concentration of a larger molecule (FITC-dextran) remains unchanged. For the first time impedance spectroscopy is introduced to monitor the salt concentration in situ in real-time in between the two desalination electrodes

    AB - Desalination as a sample preparation step is essential for noise reduction and reproducibility of mass spectrometry measurements. A specific example is the analysis of proteins for medical research and clinical applications. Salts and buffers that are present in samples need to be removed before analysis to improve the signal-to-noise ratio. Capacitive deionization is an electrostatic desalination (CDI) technique which uses two porous electrodes facing each other to remove ions from a solution. Upon the application of a potential of 0.5 V ions migrate to the electrodes and are stored in the electrical double layer. In this article we demonstrate CDI on a chip, and desalinate a solution by the removal of 23% of Na+ and Cl- ions, while the concentration of a larger molecule (FITC-dextran) remains unchanged. For the first time impedance spectroscopy is introduced to monitor the salt concentration in situ in real-time in between the two desalination electrodes

    KW - EWI-26008

    KW - IR-95880

    KW - METIS-312600

    U2 - 10.1039/c4lc01410c

    DO - 10.1039/c4lc01410c

    M3 - Article

    VL - 15

    SP - 1458

    EP - 1464

    JO - Lab on a chip

    JF - Lab on a chip

    SN - 1473-0197

    IS - 6

    ER -