Capsaicin (8%) patch increases multiple electrical nociceptive thresholds in healthy human subjects

Robert Doll, Jan R. Buitenweg, G. van Amerongen, J.L. Hay, G.J. Groeneveld, P.H. Veltink

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    Thresholds are dependent on stimulus properties and are related to different mechanisms in the nociceptive system. Measuring multiple thresholds enables a detailed observation of peripheral and central nociceptive processing. In this study, a model of capsaicin defunctionalization was used to investigate the effect on multiple simultaneously measured electrical nociceptive perception thresholds.With the presented data, increased electrical perception thresholds were observed due to capsaicin. Furthermore, this study confirms that thresholds depend on stimulus parameters. These data can be used to build a mathematical model of the nociceptive system and be used to interpret nociceptive changes.
    Original languageEnglish
    Title of host publicationPain in Europe VIII: the 8th Congress of European Federation of IASP Chapters (EFIC)
    Place of PublicationItaly
    Number of pages1
    Publication statusPublished - Oct 2013
    EventPain in Europe VIII 2013 - Fortezza da Basso, Florence, Italy
    Duration: 9 Oct 201312 Oct 2013
    Conference number: 8


    ConferencePain in Europe VIII 2013


    • BSS-Central mechanisms underlying chronic pain
    • threshold
    • Nociception
    • Pain
    • Psychophysics


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