Capsaicin (8%) patch increases multiple electrical nociceptive thresholds in healthy human subjects

Robert Doll, Jan R. Buitenweg, G. van Amerongen, J.L. Hay, G.J. Groeneveld, Petrus H. Veltink

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    Abstract

    Thresholds are dependent on stimulus properties and are related to different mechanisms in the nociceptive system. Measuring multiple thresholds enables a detailed observation of peripheral and central nociceptive processing. In this study, a model of capsaicin defunctionalization was used to investigate the effect on multiple simultaneously measured electrical nociceptive perception thresholds.With the presented data, increased electrical perception thresholds were observed due to capsaicin. Furthermore, this study confirms that thresholds depend on stimulus parameters. These data can be used to build a mathematical model of the nociceptive system and be used to interpret nociceptive changes.
    Original languageUndefined
    Title of host publicationPain in Europe VIII: the 8th Congress of European Federation of IASP Chapters (EFIC)
    Place of PublicationItaly
    PublisherEFIC
    Pages756-756
    Number of pages1
    ISBN (Print)not assigned
    Publication statusPublished - Oct 2013
    EventPain in Europe VIII 2013 - Fortezza da Basso, Florence, Italy
    Duration: 9 Oct 201312 Oct 2013
    Conference number: 8

    Publication series

    Name
    PublisherEFIC

    Conference

    ConferencePain in Europe VIII 2013
    CountryItaly
    CityFlorence
    Period9/10/1312/10/13

    Keywords

    • BSS-Central mechanisms underlying chronic pain
    • threshold
    • EWI-23807
    • METIS-300065
    • Nociception
    • Pain
    • IR-87450
    • Psychophysics

    Cite this

    Doll, R., Buitenweg, J. R., van Amerongen, G., Hay, J. L., Groeneveld, G. J., & Veltink, P. H. (2013). Capsaicin (8%) patch increases multiple electrical nociceptive thresholds in healthy human subjects. In Pain in Europe VIII: the 8th Congress of European Federation of IASP Chapters (EFIC) (pp. 756-756). Italy: EFIC.