Carbohydrate-Based Nanocarriers Exhibiting Specific Cell Targeting with Minimum Influence from the Protein Corona

Biao Kang, Patricia Okwieka, Susanne Schöttler, Svenja Winzen, Jens Langhanki, Kristin Mohr, Till Opatz, Volker Mailänder, Katharina Landfester*, Frederik R. Wurm

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

86 Citations (Scopus)

Abstract

Whenever nanoparticles encounter biological fluids like blood, proteins adsorb on their surface and form a so-called protein corona. Although its importance is widely accepted, information on the influence of surface functionalization of nanocarriers on the protein corona is still sparse, especially concerning how the functionalization of PEGylated nanocarriers with targeting agents will affect protein corona formation and how the protein corona may in turn influence the targeting effect. Herein, hydroxyethyl starch nanocarriers (HES-NCs) were prepared, PEGylated, and modified on the outer PEG layer with mannose to target dendritic cells (DCs). Their interaction with human plasma was then studied. Low overall protein adsorption with a distinct protein pattern and high specific affinity for DC binding were observed, thus indicating an efficient combination of "stealth" and targeting behavior.

Original languageEnglish
Pages (from-to)7436-7440
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number25
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • calorimetry
  • carbohydrates
  • drug delivery
  • nanoparticles
  • proteins

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