Carbohydrate nanocarriers in biomedical applications: Functionalization and construction

Biao Kang, Till Opatz, Katharina Landfester, Frederik R. Wurm*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

108 Citations (Scopus)

Abstract

The specific targeting of either tumor cells or immune cells in vivo by carefully designed and appropriately surface-functionalized nanocarriers may become an effective therapeutic treatment for a variety of diseases. Carbohydrates, which are prominent biomolecules, have shown their outstanding ability in balancing the biocompatibility, stability, biodegradability, and functionality of nanocarriers. The recent applications of sugar (mono/oligosaccharides and/or polysaccharides) for the development of nanomedicines are summarized in this review, including the application of carbohydrates for the surface-functionalization of various nanocarriers and for the construction of the nanocarrier itself. Current problems and challenges are also addressed.

Original languageEnglish
Pages (from-to)8301-8325
Number of pages25
JournalChemical Society reviews
Volume44
Issue number22
DOIs
Publication statusPublished - 21 Nov 2015
Externally publishedYes

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