Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Pauline Neirynck, P. Neirynck, J. Schimer, Pascal Jonkheijm, L.G. Milroy, P. Cigler, Luc Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)
72 Downloads (Pure)

Abstract

Supramolecular chemistry provides an attractive entry to generate dynamic and well-controlled bioactive surfaces. Novel host–guest systems are urgently needed to provide a broader affinity and applicability portfolio. A synthetic strategy to carborane–peptide bioconjugates was therefore developed to provide an entry to monovalent supramolecular functionalization of β-cyclodextrin coated surfaces. The β-cyclodextrin·carborane–cRGD surfaces are formed efficiently and with high affinity as demonstrated by IR-RAS, WCA, and QCM-D, compare favourable to existing bio-active host–guest surface assemblies, and display an efficient bioactivity, as illustrated by a strong functional effect of the supramolecular system on the cell adhesion and spreading properties. Cells seeded on the supramolecular surface displaying bioactive peptide epitopes exhibited a more elongated morphology, focal adhesions, and stronger cell adhesion compared to control surfaces. This highlights the macroscopic functionality of the novel supramolecular immobilization strategy.
Original languageUndefined
Pages (from-to)539-545
Number of pages7
JournalJournal of materials chemistry. B: materials for biology and medicine
Volume3
DOIs
Publication statusPublished - 2015

Keywords

  • METIS-314660
  • IR-99894

Cite this