Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

Harsha D. Devalla, Robert Passier (Corresponding Author)

Research output: Contribution to journalReview articleAcademicpeer-review

5 Citations (Scopus)
10 Downloads (Pure)

Abstract

Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.

Original languageEnglish
Article numbereaah5457
JournalScience Translational Medicine
Volume10
Issue number435
DOIs
Publication statusPublished - 4 Apr 2018

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Pluripotent Stem Cells
Regenerative Medicine
Tissue Engineering
Cardiac Myocytes
Heart Diseases
Health

Cite this

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Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease. / Devalla, Harsha D.; Passier, Robert (Corresponding Author).

In: Science Translational Medicine, Vol. 10, No. 435, eaah5457, 04.04.2018.

Research output: Contribution to journalReview articleAcademicpeer-review

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