Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

Harsha D. Devalla*, Robert Passier (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

18 Citations (Scopus)
102 Downloads (Pure)

Abstract

Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.

Original languageEnglish
Article numbereaah5457
JournalScience Translational Medicine
Volume10
Issue number435
DOIs
Publication statusPublished - 4 Apr 2018

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