Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

Harsha D. Devalla; Robert Passier

doi:10.1126/scitranslmed.aah5457

Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

Harsha D. Devalla^*
, Robert Passier (Corresponding Author)

^*Corresponding author for this work

Applied Stem Cell Technologies

Research output: Contribution to journal › Review article › Academic › peer-review

65 Citations (Scopus)

406 Downloads (Pure)

Abstract

Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.

Original language	English
Article number	eaah5457
Journal	Science Translational Medicine
Volume	10
Issue number	435
DOIs	https://doi.org/10.1126/scitranslmed.aah5457
Publication status	Published - 4 Apr 2018

Keywords

2019 OA procedure

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10.1126/scitranslmed.aah5457

Devalla_and_Passier_Science_Translational_Medicine_2018Final published version, 685 KBLicence: Taverne

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title = "Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease",

abstract = "Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.",

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AU - Passier, Robert

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AB - Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.

KW - 2019 OA procedure

UR - https://www.scopus.com/pages/publications/85045110754

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DO - 10.1126/scitranslmed.aah5457

M3 - Review article

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Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

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