Cardiovascular risk factors and probability for cardiovascular events in HIV-infected patients - Part III: Age differences

Till Neumann*, T. Woiwod, A. Neumann, M. Miller, C. von Birgelen, L. Volbracht, S. Esser, N. Brockmeyer, G. Gerken, R. Erbel

*Corresponding author for this work

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    Abstract

    Objective: In recent years, concerns have been growing about an elevated rate of cardiovascular diseases in HIV-infected patients due to side effects of antiretroviral therapy. The present study analyses the cardiovascular risk profile and the probability of cardiovascular events with regard to the age of HIV-infected patients. Methods: Cardiovascular risk factors of 309 HIV-infected adults were analysed. Patients were divided into four groups: 18-30 years (group 1), 31-40 years (group 2), 41-50 years (group 3), > 50 years (group 4). Overall 10-years probability for cardiovascular events was evaluated by the Framingham algorithm. Results: Differences between the groups were detected in cardiovascular risk factors including changes in lipid- and glucose metabolism. Lipid values increased with elevated age, such as total cholesterol concentration (group 1 vs. group 4: 4.71 ± 0.20 to 6.36 ± 0.21 mmol/L, p < 0.05), LDL-cholesterol concentration (2.86 ± 0.17 vs. 4.17 ± 0.21 mmol/L, p < 0.05) and triglyceride concentration (1.56 ± 0.14 vs. 3.48 ± 0.40 mmol/L, p < 0.05). HDL-cholesterol concentration (Mean ± SEM: 1.15 ± 0.03 mmol/L) did not show a significant different. Glucose concentration increased with elevated age in HIV-infected patients (5.28 ± 0.19 vs. 6.46 ± 0.24 mmHg, p < 0.05), but there was no significant difference in HbA1c - concentration, blood pressure and smoking rate between the groups. The overall 10-years probability for cardiovascular events was higher in group 1 (median: 1.9%) than in group 4 (20.5%; p < 0.01). Conclusions: The risk of cardiovascular events is related to the age in HIV-infected patients. Therefore, an increased duration of life due to a more effective antiretroviral therapy will have a significant impact on the rate of cardiovascular events in this patient population. In the future, further increase of cardiovascular events in HIV-infected patients may be expected.

    Original languageEnglish
    Pages (from-to)267-272
    Number of pages6
    JournalEuropean Journal of Medical Research
    Volume9
    Issue number5
    Publication statusPublished - 1 Dec 2004

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    Keywords

    • Age
    • Arteriosclerosis
    • Cardiovascular risk factors
    • HIV

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