Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain

Carlo Alberto Paggi; Bastien Venzac; Jeroen Leijten; Liliana Moreira Teixeira Leijten; Marcel Karperien; Séverine Le Gac

Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain

Carlo Alberto Paggi^*, Bastien Venzac, Jeroen Leijten, Liliana Moreira Teixeira Leijten, Marcel Karperien, Séverine Le Gac

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Here, we present a cartilage-on-chip platform comprising an innovative multi-modal actuation unit to subject chondrocyte-laden hydrogel to both compression and shear strain. The response of human chondrocytes to both healthy and pathophysiological mechanical stimulation is evaluated.

Original language	English
Title of host publication	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Publisher	The Chemical and Biological Microsystems Society
Pages	406-407
Number of pages	2
ISBN (Electronic)	9781733419000
Publication status	Published - 2019
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 Conference number: 23 https://cbmsociety.org/microtas/microtas2019/

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019
Abbreviated title	MicroTAS 2019
Country/Territory	Switzerland
City	Basel
Period	27/10/19 → 31/10/19
Internet address	https://cbmsociety.org/microtas/microtas2019/

Keywords

Articular cartilage
Cartilage-on-chip
Mechanical stimuli

Cite this

Paggi, C. A., Venzac, B., Leijten, J., Leijten, L. M. T., Karperien, M., & Le Gac, S. (2019). Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 406-407). The Chemical and Biological Microsystems Society.

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title = "Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain",

abstract = "Here, we present a cartilage-on-chip platform comprising an innovative multi-modal actuation unit to subject chondrocyte-laden hydrogel to both compression and shear strain. The response of human chondrocytes to both healthy and pathophysiological mechanical stimulation is evaluated.",

keywords = "Articular cartilage, Cartilage-on-chip, Mechanical stimuli",

author = "Paggi, {Carlo Alberto} and Bastien Venzac and Jeroen Leijten and Leijten, {Liliana Moreira Teixeira} and Marcel Karperien and {Le Gac}, S{\'e}verine",

year = "2019",

language = "English",

pages = "406--407",

booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",

publisher = "The Chemical and Biological Microsystems Society",

note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",

url = "https://cbmsociety.org/microtas/microtas2019/",

}

Paggi, CA, Venzac, B, Leijten, J , Leijten, LMT , Karperien, M & Le Gac, S 2019, Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. The Chemical and Biological Microsystems Society, pp. 406-407, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, Basel, Switzerland, 27/10/19.

Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain. / Paggi, Carlo Alberto; Venzac, Bastien; Leijten, Jeroen et al.
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. The Chemical and Biological Microsystems Society, 2019. p. 406-407.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Cartilage-on-chip

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019

AU - Paggi, Carlo Alberto

AU - Venzac, Bastien

AU - Leijten, Jeroen

AU - Leijten, Liliana Moreira Teixeira

AU - Karperien, Marcel

AU - Le Gac, Séverine

N1 - Conference code: 23

PY - 2019

Y1 - 2019

N2 - Here, we present a cartilage-on-chip platform comprising an innovative multi-modal actuation unit to subject chondrocyte-laden hydrogel to both compression and shear strain. The response of human chondrocytes to both healthy and pathophysiological mechanical stimulation is evaluated.

AB - Here, we present a cartilage-on-chip platform comprising an innovative multi-modal actuation unit to subject chondrocyte-laden hydrogel to both compression and shear strain. The response of human chondrocytes to both healthy and pathophysiological mechanical stimulation is evaluated.

KW - Articular cartilage

KW - Cartilage-on-chip

KW - Mechanical stimuli

UR - http://www.scopus.com/inward/record.url?scp=85094953498&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85094953498

SP - 406

EP - 407

BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

PB - The Chemical and Biological Microsystems Society

Y2 - 27 October 2019 through 31 October 2019

ER -

Cartilage-on-chip: A physiologically inspired platform to reproduce articular joint compression and shear strain

Abstract

Conference

Keywords

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