Cartilage repair in an osteochondral defect in a rabbit model

V. Barron, K. Merghani, A. Nandakumar, Clemens van Blitterswijk, Pamela Habibovic, G. Shaw, C. Coleman, J. Hayes, Lorenzo Moroni, F. Barry, M. Murphy

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    Abstract

    Despite the fact that mesenchymal stem cells (MSC) offer clinical potential for osteoarthritis applications, retaining sufficient numbers of functional MSC at the site of injury for optimal repair still continues to be a major challenge. One method of overcoming this limitation is to create an artificial extracellular matrix or scaffold to hold the cells in place. Previous research suggests that biomaterials possessing an elastic modulus between 2-50MPa are suitable for functional cartilage repair. To this end, the main aim of this study was to examine the effect of scaffold mechanical properties on cartilage repair in a rabbit model in vivo.
    Original languageEnglish
    Article number213
    Pages (from-to)S120-S120
    Number of pages1
    JournalOsteoarthritis and cartilage
    Volume21
    Issue numbersupplement
    DOIs
    Publication statusPublished - 2013

    Keywords

    • IR-91547
    • METIS-300615

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