Cartilage repair in an osteochondral defect in a rabbit model

V. Barron; K. Merghani; A. Nandakumar; Clemens van Blitterswijk; Pamela Habibovic; G. Shaw; C. Coleman; J. Hayes; Lorenzo Moroni; F. Barry; M. Murphy

doi:10.1016/j.joca.2013.02.253

Cartilage repair in an osteochondral defect in a rabbit model

V. Barron, K. Merghani, A. Nandakumar, Clemens van Blitterswijk, Pamela Habibovic, G. Shaw, C. Coleman, J. Hayes, Lorenzo Moroni, F. Barry, M. Murphy

Research output: Contribution to journal › Article › Academic › peer-review

90 Downloads (Pure)

Abstract

Despite the fact that mesenchymal stem cells (MSC) offer clinical potential for osteoarthritis applications, retaining sufficient numbers of functional MSC at the site of injury for optimal repair still continues to be a major challenge. One method of overcoming this limitation is to create an artificial extracellular matrix or scaffold to hold the cells in place. Previous research suggests that biomaterials possessing an elastic modulus between 2-50MPa are suitable for functional cartilage repair. To this end, the main aim of this study was to examine the effect of scaffold mechanical properties on cartilage repair in a rabbit model in vivo.

Original language	English
Article number	213
Pages (from-to)	S120-S120
Number of pages	1
Journal	Osteoarthritis and cartilage
Volume	21
Issue number	supplement
DOIs	https://doi.org/10.1016/j.joca.2013.02.253
Publication status	Published - 2013

Keywords

IR-91547
METIS-300615

Access to Document

10.1016/j.joca.2013.02.253

cartilage

Cite this

@article{4b85d43fa65d471a98d9a0a731a517b3,

title = "Cartilage repair in an osteochondral defect in a rabbit model",

abstract = "Despite the fact that mesenchymal stem cells (MSC) offer clinical potential for osteoarthritis applications, retaining sufficient numbers of functional MSC at the site of injury for optimal repair still continues to be a major challenge. One method of overcoming this limitation is to create an artificial extracellular matrix or scaffold to hold the cells in place. Previous research suggests that biomaterials possessing an elastic modulus between 2-50MPa are suitable for functional cartilage repair. To this end, the main aim of this study was to examine the effect of scaffold mechanical properties on cartilage repair in a rabbit model in vivo.",

keywords = "IR-91547, METIS-300615",

author = "V. Barron and K. Merghani and A. Nandakumar and {van Blitterswijk}, Clemens and Pamela Habibovic and G. Shaw and C. Coleman and J. Hayes and Lorenzo Moroni and F. Barry and M. Murphy",

note = "Abstracts from the 2014 World Congress ",

year = "2013",

doi = "10.1016/j.joca.2013.02.253",

language = "English",

volume = "21",

pages = "S120--S120",

journal = "Osteoarthritis and cartilage",

issn = "1063-4584",

publisher = "W.B. Saunders Ltd",

number = "supplement",

}

TY - JOUR

T1 - Cartilage repair in an osteochondral defect in a rabbit model

AU - Barron, V.

AU - Merghani, K.

AU - Nandakumar, A.

AU - van Blitterswijk, Clemens

AU - Habibovic, Pamela

AU - Shaw, G.

AU - Coleman, C.

AU - Hayes, J.

AU - Moroni, Lorenzo

AU - Barry, F.

AU - Murphy, M.

N1 - Abstracts from the 2014 World Congress

PY - 2013

Y1 - 2013

N2 - Despite the fact that mesenchymal stem cells (MSC) offer clinical potential for osteoarthritis applications, retaining sufficient numbers of functional MSC at the site of injury for optimal repair still continues to be a major challenge. One method of overcoming this limitation is to create an artificial extracellular matrix or scaffold to hold the cells in place. Previous research suggests that biomaterials possessing an elastic modulus between 2-50MPa are suitable for functional cartilage repair. To this end, the main aim of this study was to examine the effect of scaffold mechanical properties on cartilage repair in a rabbit model in vivo.

AB - Despite the fact that mesenchymal stem cells (MSC) offer clinical potential for osteoarthritis applications, retaining sufficient numbers of functional MSC at the site of injury for optimal repair still continues to be a major challenge. One method of overcoming this limitation is to create an artificial extracellular matrix or scaffold to hold the cells in place. Previous research suggests that biomaterials possessing an elastic modulus between 2-50MPa are suitable for functional cartilage repair. To this end, the main aim of this study was to examine the effect of scaffold mechanical properties on cartilage repair in a rabbit model in vivo.

KW - IR-91547

KW - METIS-300615

U2 - 10.1016/j.joca.2013.02.253

DO - 10.1016/j.joca.2013.02.253

M3 - Article

VL - 21

SP - S120-S120

JO - Osteoarthritis and cartilage

JF - Osteoarthritis and cartilage

SN - 1063-4584

IS - supplement

M1 - 213

ER -

Cartilage repair in an osteochondral defect in a rabbit model

Abstract

Keywords

Access to Document

Fingerprint

Cite this