Cationic polymers and their therapeutic potential

S.K. Samal, Mamoni Dash, S. van Vlierberghe, D. Kaplan, E. Chiellini, Clemens van Blitterswijk, Lorenzo Moroni, P. Dubruel

Research output: Contribution to journalArticleAcademicpeer-review

469 Citations (Scopus)


The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.
Original languageEnglish
Pages (from-to)7147-7194
JournalChemical Society reviews
Issue number21
Publication statusPublished - 10 Aug 2012


  • IR-80983
  • METIS-287390


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