Cationic polymers and their therapeutic potential

S.K. Samal; Mamoni Dash; S. van Vlierberghe; D. Kaplan; E. Chiellini; Clemens van Blitterswijk; Lorenzo Moroni; P. Dubruel

doi:10.1039/c2c35094g

Cationic polymers and their therapeutic potential

S.K. Samal, Mamoni Dash, S. van Vlierberghe, D. Kaplan, E. Chiellini, Clemens van Blitterswijk, Lorenzo Moroni, P. Dubruel

Faculty of Science and Technology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.

Original language	English
Pages (from-to)	7147-7194
Journal	Chemical Society reviews
Volume	41
Issue number	21
DOIs	https://doi.org/10.1039/c2c35094g
Publication status	Published - 10 Aug 2012

Keywords

IR-80983
METIS-287390

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10.1039/c2c35094g

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abstract = "The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.",

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AU - Dash, Mamoni

AU - van Vlierberghe, S.

AU - Kaplan, D.

AU - Chiellini, E.

AU - van Blitterswijk, Clemens

AU - Moroni, Lorenzo

AU - Dubruel, P.

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AB - The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.

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JO - Chemical Society reviews

JF - Chemical Society reviews

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Cationic polymers and their therapeutic potential

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Keywords

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