Cationic polymers for intracellular delivery of proteins

G.M.J.P.C. Coué, Johannes F.J. Engbersen

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)

Abstract

Many therapeutic proteins exert their pharmaceutical action inside the cytoplasm or onto individual organelles inside the cell. Intracellular protein delivery is considered to be the most direct, fastest and safest approach for curing gene-deficiency diseases, enhancing vaccination and triggering cell transdifferentiation processes, within other curative applications. However, several hurdles have to be overcome. For this purpose the use of polymers, with their ease of modification in physical and chemical properties, is attractive in protein drug carriers. They can protect their therapeutic protein cargo from degradation and enhance their bioavailability at targeted sites. In this chapter, potential and currently used polymers for fabrication of protein delivery systems and their applications for intracellular administration are discussed. Special attention is given to the use of cationic polymers for their ability to promote the cellular uptake of therapeutic proteins.
Original languageUndefined
Title of host publicationCationic polymers in regenerative medicine
EditorsSangram Samal, Peter Dubruel
PublisherRoyal Society of Chemistry
Pages356-365
ISBN (Print)978-1-84973-937-5
DOIs
Publication statusPublished - 2015

Publication series

NameRSC polymer chemistry series
PublisherRSC
Number13

Keywords

  • METIS-315340
  • IR-99660

Cite this

Coué, G. M. J. P. C., & Engbersen, J. F. J. (2015). Cationic polymers for intracellular delivery of proteins. In S. Samal, & P. Dubruel (Eds.), Cationic polymers in regenerative medicine (pp. 356-365). (RSC polymer chemistry series; No. 13). Royal Society of Chemistry. https://doi.org/10.1039/9781782620105-00356
Coué, G.M.J.P.C. ; Engbersen, Johannes F.J. / Cationic polymers for intracellular delivery of proteins. Cationic polymers in regenerative medicine. editor / Sangram Samal ; Peter Dubruel. Royal Society of Chemistry, 2015. pp. 356-365 (RSC polymer chemistry series; 13).
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Coué, GMJPC & Engbersen, JFJ 2015, Cationic polymers for intracellular delivery of proteins. in S Samal & P Dubruel (eds), Cationic polymers in regenerative medicine. RSC polymer chemistry series, no. 13, Royal Society of Chemistry, pp. 356-365. https://doi.org/10.1039/9781782620105-00356

Cationic polymers for intracellular delivery of proteins. / Coué, G.M.J.P.C.; Engbersen, Johannes F.J.

Cationic polymers in regenerative medicine. ed. / Sangram Samal; Peter Dubruel. Royal Society of Chemistry, 2015. p. 356-365 (RSC polymer chemistry series; No. 13).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

TY - CHAP

T1 - Cationic polymers for intracellular delivery of proteins

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AU - Engbersen, Johannes F.J.

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N2 - Many therapeutic proteins exert their pharmaceutical action inside the cytoplasm or onto individual organelles inside the cell. Intracellular protein delivery is considered to be the most direct, fastest and safest approach for curing gene-deficiency diseases, enhancing vaccination and triggering cell transdifferentiation processes, within other curative applications. However, several hurdles have to be overcome. For this purpose the use of polymers, with their ease of modification in physical and chemical properties, is attractive in protein drug carriers. They can protect their therapeutic protein cargo from degradation and enhance their bioavailability at targeted sites. In this chapter, potential and currently used polymers for fabrication of protein delivery systems and their applications for intracellular administration are discussed. Special attention is given to the use of cationic polymers for their ability to promote the cellular uptake of therapeutic proteins.

AB - Many therapeutic proteins exert their pharmaceutical action inside the cytoplasm or onto individual organelles inside the cell. Intracellular protein delivery is considered to be the most direct, fastest and safest approach for curing gene-deficiency diseases, enhancing vaccination and triggering cell transdifferentiation processes, within other curative applications. However, several hurdles have to be overcome. For this purpose the use of polymers, with their ease of modification in physical and chemical properties, is attractive in protein drug carriers. They can protect their therapeutic protein cargo from degradation and enhance their bioavailability at targeted sites. In this chapter, potential and currently used polymers for fabrication of protein delivery systems and their applications for intracellular administration are discussed. Special attention is given to the use of cationic polymers for their ability to promote the cellular uptake of therapeutic proteins.

KW - METIS-315340

KW - IR-99660

U2 - 10.1039/9781782620105-00356

DO - 10.1039/9781782620105-00356

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T3 - RSC polymer chemistry series

SP - 356

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BT - Cationic polymers in regenerative medicine

A2 - Samal, Sangram

A2 - Dubruel, Peter

PB - Royal Society of Chemistry

ER -

Coué GMJPC, Engbersen JFJ. Cationic polymers for intracellular delivery of proteins. In Samal S, Dubruel P, editors, Cationic polymers in regenerative medicine. Royal Society of Chemistry. 2015. p. 356-365. (RSC polymer chemistry series; 13). https://doi.org/10.1039/9781782620105-00356