Cause-specific mortality and years of life lost in patients with different manifestations of vascular disease

Rob C.M. Kruijsdijk, Yolanda van der Graaf, Hendrik Koffijberg, Gert Jan de Borst, Hendrik M. Nathoe, L. Jaap Kappelle, Frank L.J. Visseren

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Design The design was a prospective cohort study. Methods A total of 5911 patients with stable coronary artery disease, cerebrovascular disease, peripheral artery disease (PAD), abdominal aortic aneurysm or polyvascular disease were followed-up for mortality. Cause-specific standardised mortality ratios (SMRs) and YLL, compared to the Dutch population, were estimated. Determinants for cause-specific mortality were evaluated using competing risks models. Results During a median follow-up of 6.0 years (interquartile range (IQR): 3.1–9.2), 958 (16.2%) patients died. All-cause mortality was increased compared to the general population (SMR: 1.26, 95% confidence interval (CI): 1.18–1.34). Patients with PAD and polyvascular disease were at highest risk, especially for ischaemic heart disease (SMR: 2.52, 95% CI: 1.70–3.60 and SMR: 3.97, 95% CI: 3.18–4.90, respectively). Patients with PAD were at increased risk of dying from cancer (SMR: 1.67, 95% CI: 1.25–2.17). On average, patients with vascular disease of ≥50 years died 7.8 years younger than the general population, with 80% of the excess YLL attributable to cardiovascular disease. In middle-aged patients the excess YLL were about 10 years, of which 24% were lost due to cancer. Important determinants for mortality were male gender, smoking, physical inactivity, renal insufficiency and polyvascular disease. Conclusions Patients with manifest vascular disease are at increased risk of both cardiovascular and cancer mortality, particularly patients with PAD or polyvascular disease. On average, patients with vascular disease of ≥50 years die 7.8 years younger than the general population.
Original languageEnglish
Pages (from-to)160-169
JournalEuropean journal of preventive cardiology
Volume23
Issue number2
DOIs
Publication statusPublished - 2016

Keywords

  • METIS-320527
  • IR-98484

Fingerprint Dive into the research topics of 'Cause-specific mortality and years of life lost in patients with different manifestations of vascular disease'. Together they form a unique fingerprint.

  • Cite this

    Kruijsdijk, R. C. M., van der Graaf, Y., Koffijberg, H., de Borst, G. J., Nathoe, H. M., Kappelle, L. J., & Visseren, F. L. J. (2016). Cause-specific mortality and years of life lost in patients with different manifestations of vascular disease. European journal of preventive cardiology, 23(2), 160-169. https://doi.org/10.1177/2047487314566998