Cell permeabilisation and transport focused around oscillating microbubbles

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Abstract

The ultrasound-driven oscillation of a microbubble drives a steady streaming focused around the bubble. The study of individual bubbles attached to a wall shows vivid recirculations. When cells are in the vicinity of these bubbles, also used in medecine as contrast agent for ultrasound echography, they experience considerable shear rates. We introduce in the flow giant unilamelar lipid vesicles, acting as artificial cells. Rupture of the lipidic membrane with the opening of pores is revealed by high-speed camera recordings. A reversible permeation of the membrane wall can also be obtained, demonstrating at the micron scale the efficiency of microbubbles to deliver drugs in cells. The streaming flow of bubble on a surface can be further controlled, with the adjunction of a solid obstacle nearby: the flow turns to be directed. We will present a microfluidic device using the principle of bubble/obstacle doublets to locally transport small objets such as cells.
Original languageUndefined
Title of host publicationMechanics of the 21st century: 21st International Congress of Theoretical and Applied Mechanics
EditorsWitold Gutkowski, Tomasz A. Kowalewski
Place of PublicationWarsaw, Poland
PublisherSpringer
Pages-
ISBN (Print)9781402035593
Publication statusPublished - 15 Aug 2004
EventXXI International Congress of Theoretical and Applied Mechanics, ICTAM 2004 - Warsaw, Poland
Duration: 15 Aug 200421 Aug 2004
Conference number: 21

Publication series

Name
PublisherSpringer

Conference

ConferenceXXI International Congress of Theoretical and Applied Mechanics, ICTAM 2004
Abbreviated titleICTAM
CountryPoland
CityWarsaw
Period15/08/0421/08/04

Keywords

  • METIS-218778
  • IR-47844

Cite this

Marmottant, P. G. M., Hilgenfeldt, S., Versluis, M., Gardeniers, J. G. E., van den Berg, A., & Lohse, D. (2004). Cell permeabilisation and transport focused around oscillating microbubbles. In W. Gutkowski, & T. A. Kowalewski (Eds.), Mechanics of the 21st century: 21st International Congress of Theoretical and Applied Mechanics (pp. -). Warsaw, Poland: Springer.