Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures

Jeroen Christianus Hermanus Leijten, Nicole Georgi, Ling Wu, Clemens van Blitterswijk, Hermanus Bernardus Johannes Karperien

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)
74 Downloads (Pure)

Abstract

The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise. As with all tissue engineering strategies, the possible therapeutic outcome is intimately linked with the used combination of cells, growth factors and biomaterials. However, the optimal combination has remained a controversial topic and no consensus has been reached. In consequence, much effort has been dedicated to further design, investigate and optimize cartilage repair strategies. Specifically, various research groups have performed intensive investigations attempting to identify the single most optimal cell source for articular cartilage repair strategies. However, recent findings indicate that not the heavily investigated mono cell source, but the less studied combinations of cell sources in co-culture might be more attractive for cartilage repair strategies. This review will give a comprehensive overview on the cell sources that have been investigated for articular cartilage repair strategies. In particular, the advantages and disadvantages of investigated cell sources are comprehensively discussed with emphasis on the potential of co-cultures in which benefits are combined while the disadvantages of single cell sources for cartilage repair are mitigated.
Original languageEnglish
Pages (from-to)31-40
JournalTissue engineering. Part B: Reviews
Volume19
Issue number1
DOIs
Publication statusPublished - 30 Jul 2013

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Cartilage
Articular Cartilage
Coculture Techniques
Repair
Tissue engineering
Tissue Engineering
Cell growth
Biocompatible Materials
Biomaterials
Intercellular Signaling Peptides and Proteins
Cells
Tissue
Research
Population

Keywords

  • METIS-287189
  • IR-80923

Cite this

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title = "Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures",
abstract = "The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise. As with all tissue engineering strategies, the possible therapeutic outcome is intimately linked with the used combination of cells, growth factors and biomaterials. However, the optimal combination has remained a controversial topic and no consensus has been reached. In consequence, much effort has been dedicated to further design, investigate and optimize cartilage repair strategies. Specifically, various research groups have performed intensive investigations attempting to identify the single most optimal cell source for articular cartilage repair strategies. However, recent findings indicate that not the heavily investigated mono cell source, but the less studied combinations of cell sources in co-culture might be more attractive for cartilage repair strategies. This review will give a comprehensive overview on the cell sources that have been investigated for articular cartilage repair strategies. In particular, the advantages and disadvantages of investigated cell sources are comprehensively discussed with emphasis on the potential of co-cultures in which benefits are combined while the disadvantages of single cell sources for cartilage repair are mitigated.",
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Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures. / Leijten, Jeroen Christianus Hermanus; Georgi, Nicole; Wu, Ling; van Blitterswijk, Clemens; Karperien, Hermanus Bernardus Johannes.

In: Tissue engineering. Part B: Reviews, Vol. 19, No. 1, 30.07.2013, p. 31-40.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures

AU - Leijten, Jeroen Christianus Hermanus

AU - Georgi, Nicole

AU - Wu, Ling

AU - van Blitterswijk, Clemens

AU - Karperien, Hermanus Bernardus Johannes

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N2 - The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise. As with all tissue engineering strategies, the possible therapeutic outcome is intimately linked with the used combination of cells, growth factors and biomaterials. However, the optimal combination has remained a controversial topic and no consensus has been reached. In consequence, much effort has been dedicated to further design, investigate and optimize cartilage repair strategies. Specifically, various research groups have performed intensive investigations attempting to identify the single most optimal cell source for articular cartilage repair strategies. However, recent findings indicate that not the heavily investigated mono cell source, but the less studied combinations of cell sources in co-culture might be more attractive for cartilage repair strategies. This review will give a comprehensive overview on the cell sources that have been investigated for articular cartilage repair strategies. In particular, the advantages and disadvantages of investigated cell sources are comprehensively discussed with emphasis on the potential of co-cultures in which benefits are combined while the disadvantages of single cell sources for cartilage repair are mitigated.

AB - The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise. As with all tissue engineering strategies, the possible therapeutic outcome is intimately linked with the used combination of cells, growth factors and biomaterials. However, the optimal combination has remained a controversial topic and no consensus has been reached. In consequence, much effort has been dedicated to further design, investigate and optimize cartilage repair strategies. Specifically, various research groups have performed intensive investigations attempting to identify the single most optimal cell source for articular cartilage repair strategies. However, recent findings indicate that not the heavily investigated mono cell source, but the less studied combinations of cell sources in co-culture might be more attractive for cartilage repair strategies. This review will give a comprehensive overview on the cell sources that have been investigated for articular cartilage repair strategies. In particular, the advantages and disadvantages of investigated cell sources are comprehensively discussed with emphasis on the potential of co-cultures in which benefits are combined while the disadvantages of single cell sources for cartilage repair are mitigated.

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