Cell viability studies of PEG-thiol treated gold nanorods as optoacoustic contrast agents

Srirang Manohar, R.G. Rayavarapu, Wilhelmina Petersen, Ton van Leeuwen

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

13 Citations (Scopus)

Abstract

Rod shaped gold nanoparticles are synthesized using cetyltriammonium bromide (CTAB) as a major component of growth solutions. This surfactant is toxic to cells, but is at the moment unavoidable when monodisperse and high yield nanorods are to be synthesized. CTAB is found coating side walls of the nanoparticles and plays a role in maintaining colloidal stability. It may be displaced using thiolated PEG which is non-toxic to cells. Here we report on systematic studies of cell viability of such PEGylated nanorods on an SKBR3 cell-line using the MTS assay. These PEGylated particles are characterized using electron microscopy, optical spectroscopy and zeta potential measurements. It is expected that such treatment will be crucial in making nanorods compatible for in vivo biomedical applications
Original languageUndefined
Title of host publicationPhotons Plus Ultrasound: Imaging and Sensing 2009
EditorsAlexander A. Oraevsky, Lihong V. Wang
Place of PublicationBellngham
PublisherSPIE
Pages71772D-
ISBN (Print)9780819474230
DOIs
Publication statusPublished - 24 Jan 2009
EventSPIE BIOS 2009 - San Jose, United States
Duration: 24 Jan 200929 Jan 2009

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume7177
ISSN (Print)1605-7422

Conference

ConferenceSPIE BIOS 2009
CountryUnited States
CitySan Jose
Period24/01/0929/01/09

Keywords

  • IR-77779
  • METIS-258863

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