Cellular and molecular prerequisites for bone tissue engineering

Ramakrishnaiah Siddappa

    Research output: ThesisPhD Thesis - Research UT, graduation UT

    108 Downloads (Pure)

    Abstract

    Recent advances in medicine and other biological disciplines have considerably enhanced the life expectancy of human and consequently, resulting in age related health problems including skeletal complications. In addition, bone substitute to regenerate fractures resulting from trauma, congenital and degenerative diseases adds up to the total clinical need. During the last decade a number of bone tissue engineering strategies have been implemented to overcome the limitations of the current therapies. Cell-based bone tissue engineering using Mesenchymal Stem Cells (MSCs) isolated from the bone marrow seeded on to various osteo-inductive biomaterials with osteoinductive or –conductive growth factors offers a new promise. The success of bone tissue engineering rather depends on various factors such as scaffold materials, the quality of MSCs and their survival and differentiation in the implantation site.
    Original languageEnglish
    Awarding Institution
    • University of Twente
    Supervisors/Advisors
    • van Blitterswijk, Clemens, Supervisor
    • de Boer, Jan, Co-Supervisor
    Award date14 Dec 2007
    Place of PublicationEnschede
    Publisher
    Print ISBNs978-90-365-2583-1
    Publication statusPublished - 14 Dec 2007

    Keywords

    • IR-58105

    Fingerprint Dive into the research topics of 'Cellular and molecular prerequisites for bone tissue engineering'. Together they form a unique fingerprint.

    Cite this