Cellular microtissues spontaneously formed in a microfabricated device for angiogenesis

Severine le Gac, N.C. Rivron, Nicolas Rivron, Daniël Wijnperle, Daniel Wijnperle, Clemens van Blitterswijk, Albert van den Berg

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Abstract

We report here on a microdevice for the spontaneous and simultaneous formation of microtissues -or microscale spheroids- in a fast, controlled and reproducible way. Spheroids are relevant constructs for tissue engineering applications, and notably for studying the process of angiogenesis which is of crucial importance for both tissue regeneration and understanding/manipulating tumor vascularization. Our microdevices consist of PDMS microwell arrays whose surface properties are optimized (PDMS composition and applied coating agent) for both promoting cellular aggregation into spheroids and facilitating spheroid removal out of the device.
Original languageUndefined
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences
EditorsL.E. Locascio, M. Gaitan, B.M. Paegel, D.J. Ross, W.N. Vreeland
Place of PublicationSan Diego
PublisherChemical and Biological Micro Systems Society
Pages1165-1167
Number of pages3
ISBN (Print)978-0-9798064-1-4
Publication statusPublished - 12 Oct 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2008 - San Diego, United States
Duration: 12 Oct 200816 Oct 2008
Conference number: 12

Publication series

NameMicro Total Analysis Systems
PublisherChemical and Biological Micro Systems Society
Volume2
ISSN (Print)1556-5890

Conference

Conference12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2008
Abbreviated titleMicroTAS
CountryUnited States
CitySan Diego
Period12/10/0816/10/08

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