Cerebral white matter in early puberty is associated with luteinizing hormone concentrations

J.S. Peper, R.M. Brouwer, H.G. Schnack, G.C. van Baal, M. van Leeuwen, Stéphanie Martine van den Berg, H.A. Delemarre-Van de Waal, A.L. Janke, D.L. Collins, A.C. Evans, D.I. Boomsma, R.S. Kahn, Hilleke Hulshoff Pol

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    Abstract

    Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence.Keywords: Brain structure; Luteinizing hormone; Puberty; Twins; Voxel-based morphometry; White matter
    Original languageUndefined
    Pages (from-to)909-915
    Number of pages7
    JournalPsychoneuroendocrinology
    Volume33
    Publication statusPublished - 2008

    Keywords

    • METIS-253137

    Cite this

    Peper, J. S., Brouwer, R. M., Schnack, H. G., van Baal, G. C., van Leeuwen, M., van den Berg, S. M., ... Hulshoff Pol, H. (2008). Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. Psychoneuroendocrinology, 33, 909-915.
    Peper, J.S. ; Brouwer, R.M. ; Schnack, H.G. ; van Baal, G.C. ; van Leeuwen, M. ; van den Berg, Stéphanie Martine ; Delemarre-Van de Waal, H.A. ; Janke, A.L. ; Collins, D.L. ; Evans, A.C. ; Boomsma, D.I. ; Kahn, R.S. ; Hulshoff Pol, Hilleke. / Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. In: Psychoneuroendocrinology. 2008 ; Vol. 33. pp. 909-915.
    @article{028c348ac28c45f6ac6e403c7e1c29a2,
    title = "Cerebral white matter in early puberty is associated with luteinizing hormone concentrations",
    abstract = "Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence.Keywords: Brain structure; Luteinizing hormone; Puberty; Twins; Voxel-based morphometry; White matter",
    keywords = "METIS-253137",
    author = "J.S. Peper and R.M. Brouwer and H.G. Schnack and {van Baal}, G.C. and {van Leeuwen}, M. and {van den Berg}, {St{\'e}phanie Martine} and {Delemarre-Van de Waal}, H.A. and A.L. Janke and D.L. Collins and A.C. Evans and D.I. Boomsma and R.S. Kahn and {Hulshoff Pol}, Hilleke",
    year = "2008",
    language = "Undefined",
    volume = "33",
    pages = "909--915",
    journal = "Psychoneuroendocrinology",
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    Peper, JS, Brouwer, RM, Schnack, HG, van Baal, GC, van Leeuwen, M, van den Berg, SM, Delemarre-Van de Waal, HA, Janke, AL, Collins, DL, Evans, AC, Boomsma, DI, Kahn, RS & Hulshoff Pol, H 2008, 'Cerebral white matter in early puberty is associated with luteinizing hormone concentrations' Psychoneuroendocrinology, vol. 33, pp. 909-915.

    Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. / Peper, J.S.; Brouwer, R.M.; Schnack, H.G.; van Baal, G.C.; van Leeuwen, M.; van den Berg, Stéphanie Martine; Delemarre-Van de Waal, H.A.; Janke, A.L.; Collins, D.L.; Evans, A.C.; Boomsma, D.I.; Kahn, R.S.; Hulshoff Pol, Hilleke.

    In: Psychoneuroendocrinology, Vol. 33, 2008, p. 909-915.

    Research output: Contribution to journalArticlePopular

    TY - JOUR

    T1 - Cerebral white matter in early puberty is associated with luteinizing hormone concentrations

    AU - Peper, J.S.

    AU - Brouwer, R.M.

    AU - Schnack, H.G.

    AU - van Baal, G.C.

    AU - van Leeuwen, M.

    AU - van den Berg, Stéphanie Martine

    AU - Delemarre-Van de Waal, H.A.

    AU - Janke, A.L.

    AU - Collins, D.L.

    AU - Evans, A.C.

    AU - Boomsma, D.I.

    AU - Kahn, R.S.

    AU - Hulshoff Pol, Hilleke

    PY - 2008

    Y1 - 2008

    N2 - Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence.Keywords: Brain structure; Luteinizing hormone; Puberty; Twins; Voxel-based morphometry; White matter

    AB - Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence.Keywords: Brain structure; Luteinizing hormone; Puberty; Twins; Voxel-based morphometry; White matter

    KW - METIS-253137

    M3 - Article

    VL - 33

    SP - 909

    EP - 915

    JO - Psychoneuroendocrinology

    JF - Psychoneuroendocrinology

    SN - 0306-4530

    ER -