Abstract
In this thesis the application of computer models was investigated for improving the treatment of calcified arteries in the lower limb. The computer models provide an in-depth view of the blood flow in the arteries. The models were used to investigate how and to what extent the blood flow is disturbed in case of narrowed arteries (stenosis). The impact of stents on the blood flow in patients was also assessed, which provided a novel explanation for why stents in the lower limb artery can become occluded. This is a serious complication that can lead to a cold and painful limb weeks or months after an -initially- successful treatment.
The computational models were successfully validated with pressure measurements in patients during minimally invasive interventions of diseased arteries. The models can help determine if and where invasive treatment of a diseased artery with multiple stenotic lesions is needed, and can thus be used to prevent unnecessary, risky interventions. With further developments, the models can be used during surgical planning to virtually assess the effect of various treatment options such as balloon inflation and stent placement in a patient, in order to select the treatment option that provides the best hemodynamic outcome for that patient.
The computational models were successfully validated with pressure measurements in patients during minimally invasive interventions of diseased arteries. The models can help determine if and where invasive treatment of a diseased artery with multiple stenotic lesions is needed, and can thus be used to prevent unnecessary, risky interventions. With further developments, the models can be used during surgical planning to virtually assess the effect of various treatment options such as balloon inflation and stent placement in a patient, in order to select the treatment option that provides the best hemodynamic outcome for that patient.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Thesis sponsors | |
Award date | 25 Jan 2024 |
Place of Publication | Enschede |
Publisher | |
Print ISBNs | 978-90-365-5963-8 |
Electronic ISBNs | 978-90-365-5964-5 |
DOIs | |
Publication status | Published - Jan 2024 |
Keywords
- peripheral artery disease
- computational fluid dynamics
- hemodynamics
- wall shear stress
- High-frame-rate (HFR) ultrasound
- stent
- Fractional flow reserve