CFD for peripheral artery disease: from Color For Doctors to Clinical Flow Disruption

Research output: ThesisPhD Thesis - Research UT, graduation UT

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Abstract

In this thesis the application of computer models was investigated for improving the treatment of calcified arteries in the lower limb. The computer models provide an in-depth view of the blood flow in the arteries. The models were used to investigate how and to what extent the blood flow is disturbed in case of narrowed arteries (stenosis). The impact of stents on the blood flow in patients was also assessed, which provided a novel explanation for why stents in the lower limb artery can become occluded. This is a serious complication that can lead to a cold and painful limb weeks or months after an -initially- successful treatment.

The computational models were successfully validated with pressure measurements in patients during minimally invasive interventions of diseased arteries. The models can help determine if and where invasive treatment of a diseased artery with multiple stenotic lesions is needed, and can thus be used to prevent unnecessary, risky interventions. With further developments, the models can be used during surgical planning to virtually assess the effect of various treatment options such as balloon inflation and stent placement in a patient, in order to select the treatment option that provides the best hemodynamic outcome for that patient.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Reijnen, Michel, Supervisor
  • Versluis, Michel, Supervisor
  • Groot Jebbink, Erik, Co-Supervisor
Thesis sponsors
Award date25 Jan 2024
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-5963-8 
Electronic ISBNs978-90-365-5964-5
DOIs
Publication statusPublished - Jan 2024

Keywords

  • peripheral artery disease
  • computational fluid dynamics
  • hemodynamics
  • wall shear stress
  • High-frame-rate (HFR) ultrasound
  • stent
  • Fractional flow reserve

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