Chameleon behaviour of α-synuclein: brownian dynamics simulations of protein aggregation

Ioana Mariuca Ilie

Research output: ThesisPhD Thesis - Research UT, graduation UT

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Abstract

Over the past decades a large number of studies have been carried out in order to determine the physiological function of α-synuclein and its implication in Parkinson's disease. A complementary tool to experiments are computer simulations, which are intensively used for problems for which experiments can not yet provide a clear answer. In this thesis, we focused on studying the aggregation of α-synuclein by using coarse grained representation of the protein. We introduced a polymorph patchy particle model to describe α-synuclein and have combined it with Brownian Dynamics simulations to describe the translational and rotational dynamics. In addition, to describe the chameleonic nature of the protein, we used Brownian Dynamics to describe the internal dynamics of the particles. The internal state is coupled to the interactions between the particles.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Briels, W.J., Supervisor
  • den Otter, W.K., Advisor
Award date9 Dec 2015
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-3976-0
DOIs
Publication statusPublished - 9 Dec 2015

Keywords

  • IR-98299
  • METIS-313355

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