Changes in bursting caused by learning

J. Stegenga; Jakob le Feber; Enrico Marani; Wim Rutten

Changes in bursting caused by learning

J. Stegenga, Jakob le Feber, Enrico Marani, Wim Rutten

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

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Abstract

The localization of learning in dissociated cultures to the stimulation-evaluation electrode pair was studied. The cultures were trained using the Conditional Repetitive Stimulation (CRS) algorithm, in which repetitive focal stimulation is ended when a preset ratio of desired responses is achieved. We found that CRS can be used to strengthen an initially weak stimulus-response relationship. We used estimations of the instantaneous firing frequencies per electrode during spontaneous network bursts (NBs), called phase profiles, to determine the spatial extent of the changes required to establish a new stimulus-response relationship in the network. We found significant changes in the profiles, both on the stimulated and observed electrode pair, but also at numerous other sites. The results indicate that most of the changes are uncontrolled and that the whole network is involved during learning.

Original language	Undefined
Title of host publication	Proceedings of the 6th international meeting on substrate-integrated micro electrode arrays
Place of Publication	Stuttgard, Germany
Publisher	BIOPRO Baden-Wuerttemberg GmbH, Stuttgart, Germany
Pages	87-88
Number of pages	2
ISBN (Print)	3-938345-05-5
Publication status	Published - 8 Jul 2008
Event	6th international meeting on substrate-integrated micro electrode arrays 2008 - Stuttgart, Germany Duration: 8 Jul 2008 → 11 Jul 2008 Conference number: 6

Publication series

Name
Number	XXI

Conference

Conference	6th international meeting on substrate-integrated micro electrode arrays 2008
Country/Territory	Germany
City	Stuttgart
Period	8/07/08 → 11/07/08

Keywords

EWI-13041
METIS-251066
IR-60459
BSS-Neurotechnology and cellular engineering

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Cite this

@inproceedings{0479fd04d5724b9093c2eeee39d30fb4,

title = "Changes in bursting caused by learning",

abstract = "The localization of learning in dissociated cultures to the stimulation-evaluation electrode pair was studied. The cultures were trained using the Conditional Repetitive Stimulation (CRS) algorithm, in which repetitive focal stimulation is ended when a preset ratio of desired responses is achieved. We found that CRS can be used to strengthen an initially weak stimulus-response relationship. We used estimations of the instantaneous firing frequencies per electrode during spontaneous network bursts (NBs), called phase profiles, to determine the spatial extent of the changes required to establish a new stimulus-response relationship in the network. We found significant changes in the profiles, both on the stimulated and observed electrode pair, but also at numerous other sites. The results indicate that most of the changes are uncontrolled and that the whole network is involved during learning.",

keywords = "EWI-13041, METIS-251066, IR-60459, BSS-Neurotechnology and cellular engineering",

author = "J. Stegenga and {le Feber}, Jakob and Enrico Marani and Wim Rutten",

note = "No DOI available. Only a link to the whole proceedings document exists: http://www.bio-pro.de/imperia/md/content/biopro/veranstaltungen/mea_meeting_proceedings_final.pdf Warning: No DOI or Official URL, Please give reasons; 6th international meeting on substrate-integrated micro electrode arrays 2008 ; Conference date: 08-07-2008 Through 11-07-2008",

year = "2008",

month = jul,

day = "8",

language = "Undefined",

isbn = "3-938345-05-5",

publisher = "BIOPRO Baden-Wuerttemberg GmbH, Stuttgart, Germany",

number = "XXI",

pages = "87--88",

booktitle = "Proceedings of the 6th international meeting on substrate-integrated micro electrode arrays",

}

Stegenga, J, le Feber, J, Marani, E & Rutten, W 2008, Changes in bursting caused by learning. in Proceedings of the 6th international meeting on substrate-integrated micro electrode arrays. BIOPRO Baden-Wuerttemberg GmbH, Stuttgart, Germany, Stuttgard, Germany, pp. 87-88, 6th international meeting on substrate-integrated micro electrode arrays 2008, Stuttgart, Germany, 8/07/08.

Changes in bursting caused by learning. / Stegenga, J.; le Feber, Jakob; Marani, Enrico et al.
Proceedings of the 6th international meeting on substrate-integrated micro electrode arrays. Stuttgard, Germany: BIOPRO Baden-Wuerttemberg GmbH, Stuttgart, Germany, 2008. p. 87-88.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - Changes in bursting caused by learning

AU - Stegenga, J.

AU - le Feber, Jakob

AU - Marani, Enrico

AU - Rutten, Wim

N1 - Conference code: 6

PY - 2008/7/8

Y1 - 2008/7/8

N2 - The localization of learning in dissociated cultures to the stimulation-evaluation electrode pair was studied. The cultures were trained using the Conditional Repetitive Stimulation (CRS) algorithm, in which repetitive focal stimulation is ended when a preset ratio of desired responses is achieved. We found that CRS can be used to strengthen an initially weak stimulus-response relationship. We used estimations of the instantaneous firing frequencies per electrode during spontaneous network bursts (NBs), called phase profiles, to determine the spatial extent of the changes required to establish a new stimulus-response relationship in the network. We found significant changes in the profiles, both on the stimulated and observed electrode pair, but also at numerous other sites. The results indicate that most of the changes are uncontrolled and that the whole network is involved during learning.

AB - The localization of learning in dissociated cultures to the stimulation-evaluation electrode pair was studied. The cultures were trained using the Conditional Repetitive Stimulation (CRS) algorithm, in which repetitive focal stimulation is ended when a preset ratio of desired responses is achieved. We found that CRS can be used to strengthen an initially weak stimulus-response relationship. We used estimations of the instantaneous firing frequencies per electrode during spontaneous network bursts (NBs), called phase profiles, to determine the spatial extent of the changes required to establish a new stimulus-response relationship in the network. We found significant changes in the profiles, both on the stimulated and observed electrode pair, but also at numerous other sites. The results indicate that most of the changes are uncontrolled and that the whole network is involved during learning.

KW - EWI-13041

KW - METIS-251066

KW - IR-60459

KW - BSS-Neurotechnology and cellular engineering

M3 - Conference contribution

SN - 3-938345-05-5

SP - 87

EP - 88

BT - Proceedings of the 6th international meeting on substrate-integrated micro electrode arrays

PB - BIOPRO Baden-Wuerttemberg GmbH, Stuttgart, Germany

CY - Stuttgard, Germany

T2 - 6th international meeting on substrate-integrated micro electrode arrays 2008

Y2 - 8 July 2008 through 11 July 2008

ER -