TY - JOUR
T1 - Changing iron content and excitation field
T2 - Comparative study of Synomag® nanoparticles
AU - Alic, L.
AU - Riahi, K.
AU - Horstman-van de Loosdrecht, M.M.
AU - Rietberg, Max
AU - Perez y Perez, J.
AU - Dijkstra, C.
AU - ten Haken, B.
N1 - Funding Information:
We gratefully acknowledge partial funding supports by EU Interreg Deutschland Nederland Program, project InMediValue (under award number 122207).
Publisher Copyright:
© 2022 Riahi et al.; licensee Infinite Science Publishing GmbH.
PY - 2022
Y1 - 2022
N2 - Magnetic nanoparticles (MNPs) are widely used to facilitate magnetic particle imaging (MPI) which has the potential to become the leading diagnostic instrument for biomedical imaging. This comparative study assesses the effects of changing iron content and excitation frequency on point-spread function (PSF) representing the effect of magnetization reversal. PSF is quantified by features of interest for MPI: i.e. gradient amplitude and full-width-at-half-maximum (FWHM). A superparamagnetic quantifier (SPaQ) is used to assess differential magnetic susceptibility of two commercially available MNPs: Synomag®-D50 and Synomag®-D70. For both MNPs, the signal output depends on increase in drive field frequency and amount of iron oxide, which might be hampering the sensitivity of MPI systems that perform on higher frequencies. Nevertheless, there is a clear potential of Synomag®-D for a stable MPI resolution, especially in case of 70 nm version, that is independent of either drive field frequency or amount of iron oxide.
AB - Magnetic nanoparticles (MNPs) are widely used to facilitate magnetic particle imaging (MPI) which has the potential to become the leading diagnostic instrument for biomedical imaging. This comparative study assesses the effects of changing iron content and excitation frequency on point-spread function (PSF) representing the effect of magnetization reversal. PSF is quantified by features of interest for MPI: i.e. gradient amplitude and full-width-at-half-maximum (FWHM). A superparamagnetic quantifier (SPaQ) is used to assess differential magnetic susceptibility of two commercially available MNPs: Synomag®-D50 and Synomag®-D70. For both MNPs, the signal output depends on increase in drive field frequency and amount of iron oxide, which might be hampering the sensitivity of MPI systems that perform on higher frequencies. Nevertheless, there is a clear potential of Synomag®-D for a stable MPI resolution, especially in case of 70 nm version, that is independent of either drive field frequency or amount of iron oxide.
UR - http://www.scopus.com/inward/record.url?scp=85128307876&partnerID=8YFLogxK
U2 - 10.18416/ijmpi.2022.2203053
DO - 10.18416/ijmpi.2022.2203053
M3 - Article
AN - SCOPUS:85128307876
SN - 2365-9033
VL - 8
JO - International Journal on Magnetic Particle Imaging
JF - International Journal on Magnetic Particle Imaging
IS - 1
M1 - 2203053
ER -