Changing iron content and excitation field: Comparative study of Synomag® nanoparticles

L. Alic*, K. Riahi, M. M. Horstman-Van de Loosdrecht, M. T. Rietberg, J. Perez Y Perez, C. Dijkstra, B. Ten Haken

*Corresponding author for this work

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Abstract

Magnetic nanoparticles (MNPs) are widely used to facilitate magnetic particle imaging (MPI) which has the potential to become the leading diagnostic instrument for biomedical imaging. This comparative study assesses the effects of changing iron content and excitation frequency on point-spread function (PSF) representing the effect of magnetization reversal. PSF is quantified by features of interest for MPI: i.e. gradient amplitude and full-width-at-half-maximum (FWHM). A superparamagnetic quantifier (SPaQ) is used to assess differential magnetic susceptibility of two commercially available MNPs: Synomag®-D50 and Synomag®-D70. For both MNPs, the signal output depends on increase in drive field frequency and amount of iron oxide, which might be hampering the sensitivity of MPI systems that perform on higher frequencies. Nevertheless, there is a clear potential of Synomag®-D for a stable MPI resolution, especially in case of 70 nm version, that is independent of either drive field frequency or amount of iron oxide.

Original languageEnglish
Article number2203053
JournalInternational Journal on Magnetic Particle Imaging
Volume8
Issue number1
DOIs
Publication statusPublished - 2022

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