Characterization of cellulose based sponges for wound dressings

S. Gustaite; J. Kazlauske; J. Bobokalonov; S. Perni; Victoria Dutschk; J. Liesiene; P. Prokopovich

doi:10.1016/j.colsurfa.2014.08.022

Characterization of cellulose based sponges for wound dressings

S. Gustaite, J. Kazlauske, J. Bobokalonov, S. Perni, Victoria Dutschk, J. Liesiene, P. Prokopovich

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Abstract

Cellulose based sponges were developed by freeze-drying of regenerated cellulose gels and characterizedas a potential wound dressing. Morphological characteristics were analyzed by means of micro-computedtomography. The results showed that the porosity of the sponges reached 75%, the pores were inter-connected and their size ranged from 10 to 1200 m with a mean pore diameter of 750 m. Due tohydrophilicity of cellulose and high specific surface area (14.5 mm2/mm3) the sponges possess highsorption of simulated wound fluids (approx. 210%) and high water vapour transmission ability. Dif-ferent active compounds, such as polyphenols from Calendula officinalis or Chamomilla recutita extracts(1 day diffusion experiment), silver nanoparticles (1, 2 and 4 days diffusion experiments) were immo-bilized into the sponges in order to improve wound dressing performance. Release kinetics of silvernanoparticles and polyphenols from the sponges were investigated. The sponges incorporated with sil-ver, showed antibacterial activity against Staphylococcus epidermidis. Thus, these cellulose based spongesare promising wound dressing materials for fester and infected wounds.

Original language	English
Pages (from-to)	336-342
Number of pages	7
Journal	Colloids and surfaces A: Physicochemical and engineering aspects
Volume	480
DOIs	https://doi.org/10.1016/j.colsurfa.2014.08.022
Publication status	Published - 26 Aug 2015

Keywords

METIS-308020
IR-95552

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title = "Characterization of cellulose based sponges for wound dressings",

abstract = "Cellulose based sponges were developed by freeze-drying of regenerated cellulose gels and characterizedas a potential wound dressing. Morphological characteristics were analyzed by means of micro-computedtomography. The results showed that the porosity of the sponges reached 75%, the pores were inter-connected and their size ranged from 10 to 1200 m with a mean pore diameter of 750 m. Due tohydrophilicity of cellulose and high specific surface area (14.5 mm2/mm3) the sponges possess highsorption of simulated wound fluids (approx. 210%) and high water vapour transmission ability. Dif-ferent active compounds, such as polyphenols from Calendula officinalis or Chamomilla recutita extracts(1 day diffusion experiment), silver nanoparticles (1, 2 and 4 days diffusion experiments) were immo-bilized into the sponges in order to improve wound dressing performance. Release kinetics of silvernanoparticles and polyphenols from the sponges were investigated. The sponges incorporated with sil-ver, showed antibacterial activity against Staphylococcus epidermidis. Thus, these cellulose based spongesare promising wound dressing materials for fester and infected wounds.",

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author = "S. Gustaite and J. Kazlauske and J. Bobokalonov and S. Perni and Victoria Dutschk and J. Liesiene and P. Prokopovich",

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doi = "10.1016/j.colsurfa.2014.08.022",

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T1 - Characterization of cellulose based sponges for wound dressings

AU - Gustaite, S.

AU - Kazlauske, J.

AU - Bobokalonov, J.

AU - Perni, S.

AU - Dutschk, Victoria

AU - Liesiene, J.

AU - Prokopovich, P.

PY - 2015/8/26

Y1 - 2015/8/26

N2 - Cellulose based sponges were developed by freeze-drying of regenerated cellulose gels and characterizedas a potential wound dressing. Morphological characteristics were analyzed by means of micro-computedtomography. The results showed that the porosity of the sponges reached 75%, the pores were inter-connected and their size ranged from 10 to 1200 m with a mean pore diameter of 750 m. Due tohydrophilicity of cellulose and high specific surface area (14.5 mm2/mm3) the sponges possess highsorption of simulated wound fluids (approx. 210%) and high water vapour transmission ability. Dif-ferent active compounds, such as polyphenols from Calendula officinalis or Chamomilla recutita extracts(1 day diffusion experiment), silver nanoparticles (1, 2 and 4 days diffusion experiments) were immo-bilized into the sponges in order to improve wound dressing performance. Release kinetics of silvernanoparticles and polyphenols from the sponges were investigated. The sponges incorporated with sil-ver, showed antibacterial activity against Staphylococcus epidermidis. Thus, these cellulose based spongesare promising wound dressing materials for fester and infected wounds.

AB - Cellulose based sponges were developed by freeze-drying of regenerated cellulose gels and characterizedas a potential wound dressing. Morphological characteristics were analyzed by means of micro-computedtomography. The results showed that the porosity of the sponges reached 75%, the pores were inter-connected and their size ranged from 10 to 1200 m with a mean pore diameter of 750 m. Due tohydrophilicity of cellulose and high specific surface area (14.5 mm2/mm3) the sponges possess highsorption of simulated wound fluids (approx. 210%) and high water vapour transmission ability. Dif-ferent active compounds, such as polyphenols from Calendula officinalis or Chamomilla recutita extracts(1 day diffusion experiment), silver nanoparticles (1, 2 and 4 days diffusion experiments) were immo-bilized into the sponges in order to improve wound dressing performance. Release kinetics of silvernanoparticles and polyphenols from the sponges were investigated. The sponges incorporated with sil-ver, showed antibacterial activity against Staphylococcus epidermidis. Thus, these cellulose based spongesare promising wound dressing materials for fester and infected wounds.

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KW - IR-95552

U2 - 10.1016/j.colsurfa.2014.08.022

DO - 10.1016/j.colsurfa.2014.08.022

M3 - Article

VL - 480

SP - 336

EP - 342

JO - Colloids and surfaces A: Physicochemical and engineering aspects

JF - Colloids and surfaces A: Physicochemical and engineering aspects

SN - 0927-7757

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