Characterization of poly(D,L-lactic acid) by gel permeation chromatography

J.A.P.P. van Dijk, J.A.M. Smit, F.E. Kohn, Jan Feijen

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A number of samples of poly(D,L-lactic acid) (PLA) with weight-average molecular weights Ṁw in the range 15,000-350,000 were prepared by a ring-opening polymerization. The molecular weight distributions (MWDs) of these samples were determined by gel permeation chromatography (GPC). The method involves a universal calibration of the columns on the basis of polystyrene standards and a rapid iteration algorithm leading to the establishment of the Mark-Houwink relationship. In addition, osmometry and viscometry data are presented. The effect of hydrolytic degradation on the MWD of two PLA samples was studied by GPC.
Original languageUndefined
Pages (from-to)197-208
JournalJournal of Polymer Science: Polymer Chemistry Edition
Issue number1
Publication statusPublished - 1983


  • IR-70784

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