Chemical strategies for generating protein biochips

Pascal Jonkheijm*, Dirk Weinrich, Hendrik Schröder, Christof M. Niemeyer*, Herbert Waldmann*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

497 Citations (Scopus)


Protein biochips are at the heart of many medical and bioanalytical applications. Increasing interest has been focused on surface activation and subsequent functionalization strategies for immobilizing these biomolecules. Different approaches using covalent and noncovalent chemistry are reviewed; particular emphasis is placed on the chemical specificity of protein attachment and on retention of protein function. Strategies for creating protein patterns (as opposed to protein arrays) are also outlined. An outlook on promising and challenging future directions for protein biochip research and applications is also offered.

Original languageEnglish
Pages (from-to)9618-9647
Number of pages30
JournalAngewandte Chemie - International Edition
Issue number50
Publication statusPublished - 1 Dec 2008
Externally publishedYes


  • Chemoselectivity
  • Immobilization
  • Protein biochips
  • Protein patterns
  • Regioselectivity


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